Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
Institute for Systems Biology, Seattle, WA, USA.
Cell Metab. 2024 May 7;36(5):893-911. doi: 10.1016/j.cmet.2024.03.012. Epub 2024 Apr 12.
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be "frail." Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how metabolic diseases may modify the degree of frailty in old age and suggest that frailty may predispose toward metabolic disease. Metabolic interventions that can mitigate the degree of frailty in people are reviewed. New treatment strategies developed in animal models that are poised for translation to humans are also considered. We suggest that maintaining a youthful metabolism into older age may be protective against frailty.
平均而言，衰老与细胞代谢的不利变化有关，这些过程涉及能量的储存和消耗。然而，随着人们以不同的速度衰老，并非所有老年人的代谢失调都会达到相同的程度。那些衰老速度较快的人患不良健康后果的风险更高，被称为“虚弱”。在这里，我们探讨了虚弱和代谢之间的联系，包括代谢因素和虚弱的后果。我们研究了代谢疾病如何改变老年人的虚弱程度，并表明虚弱可能导致代谢疾病。我们还审查了可以减轻人们虚弱程度的代谢干预措施。考虑了已经在动物模型中开发并准备转化为人类使用的新的治疗策略。我们认为，保持年轻的新陈代谢进入老年可能有助于预防虚弱。
