Newington Lisa, Metcalfe Alison
NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, Guy's Hospital, SE1 9RT, UK.
Florence Nightingale School of Nursing and Midwifery, King's College London, James Clerk Maxwell Building, Waterloo Road, SE1 8WA, UK.
J Clin Med Res. 2014 Jun;6(3):162-72. doi: 10.14740/jocmr1619w. Epub 2014 Mar 31.
Recruiting the desired number of research participants is frequently problematic with resulting financial and clinical implications. The views of individuals responsible for participant recruitment have not been previously reviewed. This systematic review and thematic meta-synthesis explores researchers' and clinicians' experiences and perceptions of recruiting participants to clinical research, with the aim of informing improved recruitment systems and strategies.
Studies published between January 1995 and May 2013 were identified from: Ovid MEDLINE, Ovid EMBASE, Ovid PSYCHINFO, ASSIA, British Nursing Index, Scopus, Web of Science, CINAHL and PubMed. Included studies were original peer reviewed research, with qualitative methodologies and an aim of exploring the views of clinicians and/or researchers on recruitment to clinical research. Studies discussing the recruitment of patients unable to give informed consent were excluded. The findings sections of the relevant studies were free coded to identify key concepts which were grouped into hierarchical themes. The quality of the identified studies was assessed and the relative contribution of each paper was checked to ensure individual studies did not dominate in any theme.
Eighteen relevant papers were identified which examined the views of researchers and clinicians in 10 clinical specialties. Five main themes emerged: building a research community, securing resources, the nature of research, professional identities and recruitment strategies. The views of researchers and clinicians were similar, although the role of 'researcher' was inconsistently defined.
The general experience of recruiting participants to clinical research was one of competition and compromise. Competition arose over funding, staffing and participants, and between clinical and research responsibilities. Compromise was needed to create study designs that were acceptable to patients, clinicians and researchers. Forging relationships between clinical and research teams featured extensively, however the involvement of patients and the public within the research community was rarely discussed.
招募到所需数量的研究参与者常常存在问题,会产生财务和临床方面的影响。此前尚未对负责参与者招募的人员的观点进行过审视。本系统综述和主题元综合分析探讨了研究人员和临床医生在招募临床研究参与者方面的经验和看法,目的是为改进招募系统和策略提供信息。
从以下数据库中检索1995年1月至2013年5月发表的研究:Ovid MEDLINE、Ovid EMBASE、Ovid PSYCHINFO、ASSIA、英国护理索引、Scopus、科学引文索引、CINAHL和PubMed。纳入的研究为经同行评审的原创性研究,采用定性研究方法,旨在探讨临床医生和/或研究人员对临床研究招募工作的看法。排除讨论招募无法给出知情同意的患者的研究。对相关研究的结果部分进行自由编码,以识别关键概念,并将其分组为层次主题。评估所识别研究的质量,并检查每篇论文的相对贡献,以确保个别研究在任何主题中都不占主导地位。
共识别出18篇相关论文,这些论文考察了10个临床专科的研究人员和临床医生的观点。出现了五个主要主题:建立研究群体、获取资源、研究的性质、职业身份和招募策略。研究人员和临床医生的观点相似,尽管“研究人员”的角色定义不一致。
招募临床研究参与者的总体经历是竞争与妥协并存。在资金、人员配备和参与者方面存在竞争,临床职责和研究职责之间也存在竞争。需要做出妥协,以制定出患者、临床医生和研究人员都能接受的研究设计。临床团队与研究团队之间建立关系的情况很常见,然而患者和公众在研究群体中的参与很少被讨论。