Aldhalimi Muhsin A, Hadi Najah R, Ghafil Fadaa A
Department of Dermatology, Kufa College of Medicine, Kufa, Iraq.
Department of Pharmacology and Therapeutics, Kufa College of Medicine, Kufa, Iraq.
ISRN Pharmacol. 2014 Mar 9;2014:575423. doi: 10.1155/2014/575423. eCollection 2014.
Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. Minoxidil is a vasodilatory medication used primarily as antihypertensive drug. It was discovered to have the side effect of hair growth and reversing baldness. Tretinoin is commonly used topically for acne treatment and in the treatment of photoaging. It is used by some as hair loss treatment. Objective. To compare the stimulatory effect of Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on hair growth in a mouse model. Materials and Methods. Coat hairs on the dorsal skin of seven weeks old male mice were gently clipped and then stained by using commercial dye. These mice were divided into four groups each of five treated with topical application of ethanol 95%, Ketoconazole solution 2%, Minoxidil solution 5%, and Minoxidil with Tretinoin solution 0.1%, respectively. The drugs were applied once daily for three weeks, the clipped area was photographed, and the ratio of regrown coat area was calculated. Results. The results demonstrated that Ketoconazole, Minoxidil, and Minoxidil with Tretinoin had a significant stimulatory effect on hair growth compared with the control group and Minoxidil was the most effective drug among them.
最近有报道称，局部使用2%酮康唑溶液对雄激素性脱发有治疗作用。米诺地尔是一种血管舒张药物，主要用作抗高血压药物。它被发现有促进头发生长和逆转脱发的副作用。维甲酸通常局部用于治疗痤疮和光老化。有些人用它来治疗脱发。目的。比较酮康唑、米诺地尔以及米诺地尔与维甲酸对小鼠模型毛发生长的刺激作用。材料与方法。轻轻剪掉7周龄雄性小鼠背部皮肤的被毛，然后用商用染料染色。将这些小鼠分为四组，每组五只，分别局部涂抹95%乙醇、2%酮康唑溶液、5%米诺地尔溶液和0.1%米诺地尔与维甲酸溶液。每天给药一次，持续三周，拍摄剪毛区域的照片，并计算再生被毛面积的比例。结果。结果表明，与对照组相比，酮康唑、米诺地尔以及米诺地尔与维甲酸对毛发生长有显著的刺激作用，其中米诺地尔是最有效的药物。
