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间充质干细胞来源的细胞外囊泡在体外激活真皮乳头细胞，并促进毛囊从休止期向生长期转化在小鼠。

Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice.

机构信息

Department of Nuclear Medicine, Kyungpook National University School of Medicine/Hospital, Daegu, 700-721, Republic of Korea.

Department of Immunology, Kyungpook National University School of Medicine, Daegu, 700-721, Republic of Korea.

出版信息

Sci Rep. 2017 Nov 14;7(1):15560. doi: 10.1038/s41598-017-15505-3.

DOI:10.1038/s41598-017-15505-3
PMID:29138430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5686117/
Abstract

Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model. MSC-EV treatment increased DP cell proliferation and migration, and elevated the levels of Bcl-2, phosphorylated Akt and ERK. In addition; DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1. Intradermal injection of MSC-EVs into C57BL/6 mice promoted the conversion from telogen to anagen and increased expression of wnt3a, wnt5a and versican was demonstrated. The first time our results suggest that MSC-EVs have a potential to activate DP cells, prolonged survival, induce growth factor activation in vitro, and promotes hair growth in vivo.

摘要

脱发是一种常见的医学问题。在这项研究中，我们研究了人真皮乳头（DP）细胞在存在或不存在间充质干细胞细胞外囊泡（MSC-EV）治疗的情况下的增殖、迁移和生长因子表达。此外，我们还在动物模型中测试了 MSC-EV 治疗对毛发生长的疗效。MSC-EV 处理增加了 DP 细胞的增殖和迁移，并提高了 Bcl-2、磷酸化 Akt 和 ERK 的水平。此外，用 MSC-EVs 处理的 DP 细胞显示出增加的 VEGF 和 IGF-1 的表达和分泌。将 MSC-EVs 皮内注射到 C57BL/6 小鼠中，促进了从休止期向生长期的转化，并证明了 wnt3a、wnt5a 和 versican 的表达增加。我们的研究结果首次表明，MSC-EVs 具有激活 DP 细胞、延长存活时间、诱导生长因子体外激活以及促进体内毛发生长的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/a1690a9f81da/41598_2017_15505_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/a1690a9f81da/41598_2017_15505_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/97d1d436eda9/41598_2017_15505_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/abf3101b1ae4/41598_2017_15505_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/564b2dc675c7/41598_2017_15505_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/53124f1b7bd8/41598_2017_15505_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/ed74daf10f73/41598_2017_15505_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/53805c042c04/41598_2017_15505_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ca0/5686117/a1690a9f81da/41598_2017_15505_Fig7_HTML.jpg

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