利多卡因、氯诺昔康和硝酸甘油联合用于静脉区域麻醉时的围术期及术后镇痛特性

Peri- and postanalgesic properties of lidokain, lornoxicam, and nitroglycerine combination at intravenous regional anesthesia.

作者信息

Cakmak Biricik Melis, Cakmak Gokhan, Akpek Elif, Arslan Gulnaz, Sahin Mehmet Sukru

机构信息

Anesthesiology and Reanimation Department, Baskent University School of Medicine, Baskent University, Alanya Hospital, Saray Mah, Kızlarpınarı Caddesi No. 1, 07400 Alanya, Antalya, Turkey.

Orthopedics and Traumatology Department, Baskent University School of Medicine, Baskent University, Alanya Hospital, Saray Mah, Kızlarpınarı Caddesi No. 1, 07400 Alanya, Antalya, Turkey.

出版信息

Biomed Res Int. 2014;2014:737109. doi: 10.1155/2014/737109. Epub 2014 Mar 9.

DOI:10.1155/2014/737109

PMID:24734241

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3966418/

Abstract

BACKGROUND

This study was conducted to compare and evaluate the effect of adding lornoxicam or nitroglycerine as adjuncts to lidocaine in intravenous regional anesthesia (IVRA).

METHODS

60 patients were randomly separated into three groups, lidocaine group (group L), lidocaine+lornoxicam group (group LL), and lidocaine+lornoxicam+transdermal nitroglycerine group (group LL-N). Hemodynamic parameters, sensory and motor blocks onset, and recovery times were recorded. Analgesic consumption for tourniquet pain and postoperative period were recorded.

RESULTS

Sensory block onset times and motor block onset times were shorter in the LL-N and LL groups compared with L group. Sensory block recovery time and motor block recovery time were prolonged in the LL and LL-N groups compared with group L. The amount of fentanyl required for tourniquet pain was less in group LL and group LL-N when compared with group L. VAS scores of tourniquet pain were higher in group L compared with the other study groups. Postoperative VAS scores were higher for the first 4 hours in group L compared with the other study groups.

CONCLUSION

The adjuvant drugs (lornoxicam or TNG) when added to lidocaine in IVRA were effective in improving the overall quality of anesthesia, reducing tourniquet pain, increasing tourniquet tolerance, and improving the postoperative analgesia.

摘要

背景

本研究旨在比较和评估在静脉区域麻醉（IVRA）中添加氯诺昔康或硝酸甘油作为利多卡因辅助药物的效果。

方法

60例患者随机分为三组，利多卡因组（L组）、利多卡因+氯诺昔康组（LL组）和利多卡因+氯诺昔康+经皮硝酸甘油组（LL-N组）。记录血流动力学参数、感觉和运动阻滞起效时间及恢复时间。记录止血带疼痛和术后阶段的镇痛药物消耗量。

结果

与L组相比，LL-N组和LL组的感觉阻滞起效时间和运动阻滞起效时间更短。与L组相比，LL组和LL-N组的感觉阻滞恢复时间和运动阻滞恢复时间延长。与L组相比，LL组和LL-N组止血带疼痛所需芬太尼量更少。与其他研究组相比，L组止血带疼痛的视觉模拟评分（VAS）更高。与其他研究组相比，L组术后前4小时的VAS评分更高。