RNA二级结构中常见基序的检测。
Detection of common motifs in RNA secondary structures.
作者信息
Margalit H, Shapiro B A, Oppenheim A B, Maizel J V
机构信息
Laboratory of Mathematical Biology, National Cancer Institute, Bethesda, MD 20892.
出版信息
Nucleic Acids Res. 1989 Jun 26;17(12):4829-45. doi: 10.1093/nar/17.12.4829.
Abstract
We describe a novel computerized system for comparison of RNA secondary structures and demonstrate its use for experimental studies. The system is able to screen a very large number of structures, to cluster similar structures and to detect specific structural motifs. In particular, the system is useful for detecting mutations with specific structural effects among all possible point mutations, and for predicting compensatory mutations that will restore the wild type structure. The algorithms are independent of the folding rules that are used to generate the secondary structures.
摘要
我们描述了一种用于比较RNA二级结构的新型计算机系统，并展示了其在实验研究中的应用。该系统能够筛选大量结构，对相似结构进行聚类，并检测特定的结构基序。特别是，该系统可用于在所有可能的点突变中检测具有特定结构效应的突变，以及预测能够恢复野生型结构的补偿性突变。这些算法独立于用于生成二级结构的折叠规则。
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