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Feedback regulation of ribosomal protein gene expression in Escherichia coli: structural homology of ribosomal RNA and ribosomal protein MRNA.大肠杆菌中核糖体蛋白基因表达的反馈调节：核糖体RNA与核糖体蛋白mRNA的结构同源性
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7084-8. doi: 10.1073/pnas.77.12.7084.
2
Translational regulation by ribosomal protein S8 in Escherichia coli: structural homology between rRNA binding site and feedback target on mRNA.核糖体蛋白S8在大肠杆菌中的翻译调控：rRNA结合位点与mRNA上反馈靶点之间的结构同源性
Nucleic Acids Res. 1981 Apr 10;9(7):1757-64. doi: 10.1093/nar/9.7.1757.
3
Translational feedback regulation of the gene for L35 in Escherichia coli requires binding of ribosomal protein L20 to two sites in its leader mRNA: a possible case of ribosomal RNA-messenger RNA molecular mimicry.大肠杆菌中L35基因的翻译反馈调控需要核糖体蛋白L20与其前导mRNA中的两个位点结合：核糖体RNA-信使RNA分子模拟的一个可能实例。
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本文引用的文献

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E. coli ribosomal protein L4 is a feedback regulatory protein.大肠杆菌核糖体蛋白L4是一种反馈调节蛋白。
Cell. 1980 Sep;21(2):517-22. doi: 10.1016/0092-8674(80)90489-4.
2
Autogenous control of Escherichia coli ribosomal protein L10 synthesis in vitro.体外大肠杆菌核糖体蛋白L10合成的自体调控
Proc Natl Acad Sci U S A. 1980 May;77(5):2592-5. doi: 10.1073/pnas.77.5.2592.
3
Autogenous regulation of the synthesis of ribosomal proteins, L10 and L7/12, in Escherichia coli.大肠杆菌中核糖体蛋白L10和L7/12合成的自体调控
Mol Gen Genet. 1980;178(2):483-6. doi: 10.1007/BF00270505.
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DNA sequences from the str operon of Escherichia coli.来自大肠杆菌str操纵子的DNA序列。
J Biol Chem. 1980 May 25;255(10):4660-6.
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Effect of ultraviolet irradiation on 30-S ribosomal subunits. Identification of the RNA region crosslinked to protein S7.紫外线照射对30-S核糖体亚基的影响。与蛋白质S7交联的RNA区域的鉴定。
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In vitro expression of Escherichia coli ribosomal protein genes: autogenous inhibition of translation.大肠杆菌核糖体蛋白基因的体外表达：翻译的自体抑制
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1837-41. doi: 10.1073/pnas.77.4.1837.
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Feedback regulation of ribosomal protein gene expression in Escherichia coli.大肠杆菌中核糖体蛋白基因表达的反馈调节
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3590-4. doi: 10.1073/pnas.77.6.3590.
8
Secondary structure model for bacterial 16S ribosomal RNA: phylogenetic, enzymatic and chemical evidence.细菌16S核糖体RNA的二级结构模型：系统发育、酶学及化学证据
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9
Protein L4 of the E. coli ribosome regulates an eleven gene r protein operon.大肠杆菌核糖体的L4蛋白调控一个包含11个基因的核糖体蛋白操纵子。
Cell. 1980 Sep;21(2):523-35. doi: 10.1016/0092-8674(80)90490-0.
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DNA sequence of the promoter region for the alpha ribosomal protein operon in Escherichia coli.大肠杆菌中α核糖体蛋白操纵子启动子区域的DNA序列。
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大肠杆菌中核糖体蛋白基因表达的反馈调节：核糖体RNA与核糖体蛋白mRNA的结构同源性

Feedback regulation of ribosomal protein gene expression in Escherichia coli: structural homology of ribosomal RNA and ribosomal protein MRNA.

作者信息

Nomura M, Yates J L, Dean D, Post L E

出版信息

Proc Natl Acad Sci U S A. 1980 Dec;77(12):7084-8. doi: 10.1073/pnas.77.12.7084.

DOI:10.1073/pnas.77.12.7084
PMID:7012833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC350445/
Abstract

Certain ribosomal proteins (r proteins) in Escherichia coli, such as S4 and S7, function as feedback repressors in the regulation of r-protein synthesis. These proteins inhibit the translation of their own mRNA. The repressor r proteins so far identified are also known to bind specifically to rRNA at an initial stage in ribosome assembly. We have found structural homology between the S7 binding region on 16S rRNA and a region of the mRNA where S7 acts as a translational repressor. Similarly, there is structural homology between one of the reported S4 binding regions on 16S rRNA and the mRNA target site for S4. The observed homology supports the concept that regulation by repressor r proteins is based on competition between rRNA and mRNA for these proteins and that the same structural features and of the r proteins are used in their interactions with both rRNA and mRNA.

摘要

大肠杆菌中的某些核糖体蛋白（r蛋白），如S4和S7，在r蛋白合成的调控中作为反馈阻遏物发挥作用。这些蛋白抑制其自身mRNA的翻译。目前已鉴定出的阻遏r蛋白在核糖体组装的初始阶段也能特异性结合rRNA。我们发现16S rRNA上的S7结合区域与S7作为翻译阻遏物作用的mRNA区域之间存在结构同源性。同样，16S rRNA上报道的S4结合区域之一与S4的mRNA靶位点之间也存在结构同源性。观察到的同源性支持了这样一种概念，即阻遏r蛋白的调控基于rRNA和mRNA对这些蛋白的竞争，并且r蛋白在与rRNA和mRNA的相互作用中使用相同的结构特征。