Habenicht U F, el Etreby M F
Research Laboratories of Schering AG, Berlin/(West) Bergkamen, Federal Republic of Germany.
Pathol Res Pract. 1988 Sep;183(5):651-3. doi: 10.1016/s0344-0338(88)80034-7.
It was the goal of our studies to investigate the role of androgens and/or estrogens for the regulation of the negative feedback mechanism as well as the regulation of secretion of prolactin in male dogs and a male subhuman primate species by means of the aromatase inhibitor 1-Methyl-ADD and/or the antiandrogen cyproterone acetate. Based on our results an important but not exclusive role of estrogens in the feedback control of gonadotropic secretion in the dog and the cynomolgus monkey has been suggested. Androgens appear to be involved too. As far as prolactin is concerned it was concluded that estrogens do not always and under all conditions stimulate prolactin in primates and in dogs and that androgens also appear to stimulate prolactin in male individuals.
我们研究的目的是通过芳香化酶抑制剂1-甲基-ADD和/或抗雄激素醋酸环丙孕酮，研究雄激素和/或雌激素在雄性犬和雄性非人灵长类动物中对负反馈机制的调节作用以及催乳素分泌的调节作用。根据我们的研究结果，已表明雌激素在犬和食蟹猴促性腺激素分泌的反馈控制中起着重要但非唯一的作用。雄激素似乎也参与其中。就催乳素而言，得出的结论是，雌激素并不总是在所有条件下都刺激灵长类动物和犬的催乳素分泌，雄激素似乎也能刺激雄性个体的催乳素分泌。
