Kwok S C, Teoh W H L, Ithnin F
Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore, Singapore.
Acta Anaesthesiol Scand. 2014 Jul;58(6):743-50. doi: 10.1111/aas.12334. Epub 2014 Apr 16.
We studied the hypothesis that an equal spinal anaesthetic dose administered in the sitting position to patients undergoing post-partum tubal ligation (PPTL) and caesarean section (CS) would yield similar sensory block characteristics and analgesic efficacy.
This prospective, non-randomised trial recruited 20 women undergoing PPTL within 48 h of vaginal delivery and 20 undergoing CS. Spinal anaesthesia comprising intrathecal hyperbaric bupivacaine 12 mg and morphine 100 μg was administered at L3/4 with patients sitting. Our primary end point was the maximal dermatomal sensory block (to cold).
Baseline demographics were comparable, but PPTL patients had greater parity, with mean ± standard deviation 17.54 ± 11.2 h from delivery to spinal anaesthesia, and shorter duration of surgery, 17.54 ± 11.2 vs. 40.3 ± 15.5 min. Similar maximal sensory blocks (to cold) were achieved in group PPTL vs. CS, T4 (T1-T5) vs. T3 (T1-T5), P = 0.104, in comparable times, 8.6 ± 2.6 vs. 7.6 ± 3.0 min, P = 0.267. PPTL patients had significantly faster two-segment block regression (70.7 ± 23.5 vs. 97.6 ± 23.9 min, P = 0.001) and to T10 (120.8 ± 35.6 vs. 145.1 ± 24.3 min, P = 0.016), with less hypotension (25% vs. 65%, P = 0.025) and phenylephrine (20.0 ± 60.6 μg vs. 120.0 ± 119.6 μg, P = 0.005).
The same dose of hyperbaric bupivacaine 12 mg and morphine 100 μg administered in the sitting position to both PPTL and CS parturients yielded similar maximal sensory blocks, but PPTL exhibited faster block regression and less hypotension/vasopressor requirement.
我们研究了这样一个假设,即对于接受产后输卵管结扎术(PPTL)和剖宫产术(CS)的患者,在坐位时给予相等剂量的脊髓麻醉,会产生相似的感觉阻滞特征和镇痛效果。
这项前瞻性、非随机试验招募了20名在阴道分娩后48小时内接受PPTL的女性和20名接受CS的女性。在L3/4间隙给予包含12毫克鞘内高压布比卡因和100微克吗啡的脊髓麻醉,患者取坐位。我们的主要终点是最大皮节感觉阻滞(对冷)。
基线人口统计学特征具有可比性,但PPTL患者的产次更高,从分娩到脊髓麻醉的平均时间±标准差为17.54±11.2小时,手术时间更短,分别为17.54±11.2分钟和40.3±15.5分钟。PPTL组与CS组达到了相似的最大感觉阻滞(对冷),分别为T4(T1 - T5)和T3(T1 - T5),P = 0.104,达到阻滞的时间相当,分别为8.6±2.6分钟和7.6±3.0分钟,P = 0.267。PPTL患者的两段阻滞消退明显更快(分别为70.7±23.5分钟和97.6±23.9分钟,P = 0.001),到T10水平的消退也更快(分别为120.8±35.6分钟和145.1±24.3分钟,P = 0.016),且低血压发生率更低(25%对65%,P = 0.025),去氧肾上腺素用量更少(分别为20.0±60.6微克和120.0±119.6微克,P = 0.005)。
对PPTL和CS产妇在坐位时给予相同剂量的12毫克高压布比卡因和100微克吗啡,产生了相似的最大感觉阻滞,但PPTL的阻滞消退更快,低血压/血管升压药需求更少。