Bilgin Ahmet Burak, Turkoglu Elif Betul, Ilhan Hatice Deniz, Unal Mustafa, Apaydin Kadri Cemil
a Akdeniz University, Faculty of Medicine, Department of Ophthalmology , Antalya , Turkey.
Ocul Immunol Inflamm. 2015 Aug;23(4):283-286. doi: 10.3109/09273948.2014.909047. Epub 2014 Apr 15.
To investigate the association between smoking and prognosis of ocular Behçet disease.
MATERIAL/METHODS: Medical records of 202 patients with Behçet uveitis were collected retrospectively. Patients were assigned to two groups according to smoking habits. In group I, 72 patients were current smokers. In group II, 130 were nonsmokers. The localization of uveitis, time to resolution of uveitis, time to recurrences, visual acuities, and presence of cystoid macular edema were compared between groups.
The demographic characteristics were similar in both groups. Smoking was not associated with types of uveitis with OR of 1.01 (95% CI, 0.99-1.04; p = 0.21) for anterior uveitis, 0.96 (95%CI, 0.90-1.02; p = 0.18) for posterior uveitis, and 1.80 (95% CI, 0.75-2.77; p = 0.24) for panuveitis. The average times to inflammation resolution were 48 ± 10.1 days in group I and 51 ± 14 days in group II (p = 0.82). The average times to recurrence were 8.6 ± 5 months for smokers and 9.1 ± 7 months for nonsmokers (p = 0.43). Patients with CME in groups were 18 (25%) and 42 (32.3%), respectively (p = 0.08).
Our findings suggest that smoking does not have a negative effect on the clinical findings and prognosis of uveitis in Behçet disease.
研究吸烟与眼部白塞病预后之间的关联。
材料/方法：回顾性收集202例白塞氏葡萄膜炎患者的病历。根据吸烟习惯将患者分为两组。第一组，72例为当前吸烟者。第二组，130例为非吸烟者。比较两组葡萄膜炎的定位、葡萄膜炎消退时间、复发时间、视力以及黄斑囊样水肿的情况。
两组的人口统计学特征相似。吸烟与葡萄膜炎类型无关，前葡萄膜炎的比值比为1.01（95%可信区间，0.99 - 1.04；p = 0.21），后葡萄膜炎为0.96（95%可信区间，0.90 - 1.02；p = 0.18），全葡萄膜炎为1.80（95%可信区间，0.75 - 2.77；p = 0.24）。第一组炎症消退的平均时间为48±10.1天，第二组为51±14天（p = 0.82）。吸烟者复发的平均时间为8.6±5个月，非吸烟者为9.1±7个月（p = 0.43）。两组中患有黄斑囊样水肿的患者分别为18例（25%）和42例（32.3%）（p = 0.08）。
我们的研究结果表明，吸烟对白塞病葡萄膜炎的临床表现和预后没有负面影响。
