Yuen Brenton G, Tham Vivien M, Browne Erica N, Weinrib Rachel, Borkar Durga S, Parker John V, Uchida Aileen, Vinoya Aleli C, Acharya Nisha R
F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California; University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii.
University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii; Department of Ophthalmology, Kaiser Permanente Hawaii, Honolulu, Hawaii; Pacific Vision Institute of Hawaii, Honolulu, Hawaii.
Ophthalmology. 2015 Jun;122(6):1257-61. doi: 10.1016/j.ophtha.2015.02.034. Epub 2015 Mar 30.
To assess whether cigarette smoking is associated with the development of uveitis in a population-based setting.
Retrospective, population-based, case-control study.
Patients aged ≥ 18 years who were seen at a Kaiser Permanente Hawaii clinic between January 1, 2006, and December 31, 2007. Analysis included 100 confirmed incident uveitis cases, 522 randomly selected controls from the general Kaiser Hawaii population, and 528 randomly selected controls from the Kaiser Hawaii ophthalmology clinic.
International Classification of Diseases, 9th revision (ICD-9), diagnosis codes were used to identify possible uveitis cases. A uveitis fellowship-trained ophthalmologist then conducted individual chart review to confirm case status. Multivariate logistic regression models were used to evaluate the association between smoking and uveitis, adjusting for age, sex, race, and socioeconomic status.
Development of uveitis.
Current smokers had a 1.63 (95% confidence interval [CI], 0.88-3.00; P = 0.12) and 2.33 (95% CI, 1.22-4.45; P = 0.01) times greater odds of developing uveitis compared with those who never smoked using the general and ophthalmology control groups, respectively. The association was even stronger with noninfectious uveitis, which yielded odds ratios of 2.10 (95% CI, 1.10-3.99; P = 0.02) and 2.96 (95% CI, 1.52-5.77; P = 0.001) using the general and ophthalmology control groups, respectively.
Cigarette smoking is significantly associated with new-onset uveitis within a population-based setting. The association was stronger for noninfectious uveitis. Given the well-established risks of smoking with regard to other inflammatory disorders, these results reaffirm the importance of encouraging patients to avoid or cease smoking.
在基于人群的环境中评估吸烟是否与葡萄膜炎的发生有关。
回顾性、基于人群的病例对照研究。
2006年1月1日至2007年12月31日期间在夏威夷凯撒医疗机构就诊的年龄≥18岁的患者。分析包括100例确诊的葡萄膜炎新发病例、从夏威夷凯撒普通人群中随机选取的522名对照，以及从夏威夷凯撒眼科诊所随机选取的528名对照。
使用国际疾病分类第9版（ICD - 9）诊断代码识别可能的葡萄膜炎病例。然后由一名经过葡萄膜炎专科培训的眼科医生进行个体病历审查以确认病例状态。使用多因素逻辑回归模型评估吸烟与葡萄膜炎之间的关联，并对年龄、性别、种族和社会经济地位进行调整。
葡萄膜炎的发生。
与从不吸烟的人相比，使用普通对照组和眼科对照组时，当前吸烟者发生葡萄膜炎的几率分别高出1.63倍（95%置信区间[CI]，0.88 - 3.00；P = 0.12）和2.33倍（95%CI，1.22 - 4.45；P = 0.01）。与非感染性葡萄膜炎的关联更强，使用普通对照组和眼科对照组时，比值比分别为2.10（9�%CI，1.10 - 3.99；P = 0.02）和2.96（95%CI，1.52 - 5.77；P = 0.001）。
在基于人群的环境中，吸烟与新发葡萄膜炎显著相关。这种关联在非感染性葡萄膜炎中更强。鉴于吸烟与其他炎症性疾病的既定风险，这些结果再次强调了鼓励患者避免或戒烟的重要性。
