α-酮膦酸酯作为酯的替代物：异硫脲催化的不对称二酯和内酯合成。
α-Ketophosphonates as ester surrogates: isothiourea-catalyzed asymmetric diester and lactone synthesis.
机构信息
EaStCHEM, School of Chemistry, University of St. Andrews , North Haugh, St. Andrews KY16 9ST, U.K.
出版信息
Org Lett. 2014 May 2;16(9):2506-9. doi: 10.1021/ol500873s. Epub 2014 Apr 15.
PMID:24734989
Abstract
Isothiourea HBTM-2.1 catalyzes the asymmetric Michael addition/lactonization of aryl- and alkenylacetic acids using α-keto-β,γ-unsaturated phosphonates as α,β-unsaturated ester surrogates, giving access to a diverse range of stereodefined lactones or enantioenriched functionalized diesters upon ring-opening.
摘要
异硫脲 HBTM-2.1 可催化使用α-酮-β,γ-不饱和膦酸酯作为α,β-不饱和酯替代物的芳基和烯基乙酸的不对称迈克尔加成/内酯化反应，在开环后可得到多种立体定义的内酯或对映富集的官能化二酯。
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