Okushima Sayaka, Vettorato Enzo, Corletto Federico
Dick White Referrals, Six Mile Bottom, Cambridgeshire, UK.
Vet Anaesth Analg. 2015 Jan;42(1):88-92. doi: 10.1111/vaa.12166. Epub 2014 Apr 16.
To compare the effect of alfaxalone and propofol on heart rate (HR) and blood pressure (BP) after fentanyl administration in healthy dogs.
Prospective, randomised clinical study.
Fifty healthy client owned dogs (ASA I/II) requiring general anaesthesia for elective magnetic resonance imaging for neurological conditions.
All dogs received fentanyl 7 μg kg(-1) IV and were allocated randomly to receive either alfaxalone (n = 25) or propofol (n = 25) to effect until endotracheal (ET) intubation was possible. Heart rate and oscillometric BP were measured before fentanyl (baseline), after fentanyl (Time F) and after ET intubation (Time GA). Post-induction apnoea were recorded. Data were analysed using Fisher's exact test, Mann Whitney U test and one-way anova for repeated measures as appropriate; p value <0.05 was considered significant.
Dogs receiving propofol showed a greater decrease in HR (-14 beat minute(-1) , range -47 to 10) compared to alfaxalone (1 beat minute(-1) , range -33 to 26) (p = 0.0116). Blood pressure decreased over the three time periods with no difference between groups. Incidence of post-induction apnoea was not different between groups.
Following fentanyl administration, anaesthetic induction with propofol resulted in a greater negative chronotropic effect while alfaxalone preserved or increased HR.
Following fentanyl administration, HR decreases more frequently when propofol rather than alfaxalone is used as induction agent. However, given the high individual variability and the small change in predicted HR (-7.7 beats per minute after propofol), the clinical impact arising from choosing propofol or alfaxalone is likely to be small in healthy animals. Further studies in dogs with myocardial disease and altered haemodynamics are warranted.
比较在健康犬只中给予芬太尼后，阿法沙龙和丙泊酚对心率（HR）和血压（BP）的影响。
前瞻性随机临床研究。
五十只健康的客户拥有的犬只（美国麻醉医师协会I/II级），因神经系统疾病需接受择期磁共振成像检查而需要全身麻醉。
所有犬只静脉注射7μg/kg的芬太尼，并随机分配接受阿法沙龙（n = 25）或丙泊酚（n = 25），直至能够进行气管插管。在给予芬太尼前（基线）、给予芬太尼后（时间F）和气管插管后（时间GA）测量心率和示波血压。记录诱导后呼吸暂停情况。数据采用Fisher精确检验、Mann-Whitney U检验和重复测量的单因素方差分析进行分析；p值<0.05被认为具有统计学意义。
与阿法沙龙组（心率变化1次/分钟，范围为-33至26次/分钟）相比，丙泊酚组犬只的心率下降幅度更大（-14次/分钟，范围为-47至10次/分钟）（p = 0.0116）。在三个时间段内血压均下降，两组之间无差异。诱导后呼吸暂停的发生率在两组之间无差异。
给予芬太尼后，丙泊酚诱导麻醉导致更大的负性变时作用，而阿法沙龙则维持或增加心率。
给予芬太尼后，使用丙泊酚而非阿法沙龙作为诱导剂时，心率更频繁地下降。然而，鉴于个体差异较大且预测心率的变化较小（丙泊酚后每分钟-7.7次），在健康动物中选择丙泊酚或阿法沙龙产生的临床影响可能较小。有必要对患有心肌病和血流动力学改变的犬只进行进一步研究。
