David Laurent, Polo Jose M
INSERM, UMR 1064, Nantes, France; Faculté de Médecine, Université de Nantes, France; iPSC Facility, SFR F. Bonamy, Université de Nantes, France.
Department of Anatomy and Developmental Biology, Monash University, Australia; Australian Regenerative Medicine Institute, Monash University, Australia.
Stem Cell Res. 2014 May;12(3):754-61. doi: 10.1016/j.scr.2014.03.007. Epub 2014 Apr 1.
Despite advances in the field of somatic cell reprogramming, an understanding and exploration of the underlying mechanisms governing this process are only recently emerging. It is now increasingly apparent that key sequential events correlate with the reprogramming process; a process previously thought to be random and unpredictable is now looking, to a greater extent, defined and controlled. Herein, we will review the key cellular and molecular events associated with the reprogramming process, giving an integrative and conciliatory view of the different studies addressing the mechanism of nuclear reprogramming.
尽管体细胞重编程领域取得了进展，但对控制这一过程的潜在机制的理解和探索直到最近才开始出现。现在越来越明显的是，关键的连续事件与重编程过程相关；这个以前被认为是随机且不可预测的过程，现在在很大程度上看起来是有明确界定和可控的。在此，我们将回顾与重编程过程相关的关键细胞和分子事件，对涉及核重编程机制的不同研究给出一个综合且调和的观点。
