Kamei Atsushi, Araya Nami, Akasaka Manami, Mizuma Kanako, Asami Maya, Tanifuji Sachiko, Chida Shoichi
Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
Brain Dev. 2015 Jan;37(1):137-9. doi: 10.1016/j.braindev.2014.03.004. Epub 2014 Apr 13.
We report the case of a 7-month-old boy who developed hypofibrinogenemia (66.6 mg/dL; reference value, 170-405 mg/dL) during adrenocorticotropic hormone (ACTH) therapy for infantile spasms. Although the patient showed no clinical signs of a bleeding diathesis, we recommend that plasma fibrinogen levels should be monitored during ACTH therapy, which should be discontinued when fibrinogen levels fall below hemostatic levels (60.0mg/dL) or when bleeding tendencies are recognized.
我们报告了一名7个月大男孩的病例，该男孩在接受促肾上腺皮质激素（ACTH）治疗婴儿痉挛症期间出现了纤维蛋白原血症（66.6mg/dL；参考值为170 - 405mg/dL）。尽管该患者没有出血素质的临床症状，但我们建议在ACTH治疗期间监测血浆纤维蛋白原水平，当纤维蛋白原水平降至止血水平以下（60.0mg/dL）或出现出血倾向时，应停止治疗。
