Konishi Y, Hayakawa K, Kuriyama M, Saito M, Fujii Y, Sudo M
Department of Pediatrics, Fukui Medical School, Japan.
Pediatr Neurol. 1995 Sep;13(2):134-6. doi: 10.1016/0887-8994(95)00122-v.
Changes of the midline structures of the brain, including the pons, cerebellar vermis, and corpus callosum, induced by adrenocorticotropic hormone (ACTH) therapy in 7 infants with infantile spasms were investigated using magnetic resonance imaging. Decreased volume of these parts of the brain was induced in almost all infants. Decreased volume of the pons was thought to be closely related to sleep disturbance during ACTH therapy. These results may demonstrate that the cessation of convulsive episodes in infants with infantile spasms treated with ACTH is due to its direct action on the brainstem.
利用磁共振成像技术，对7例患有婴儿痉挛症的婴儿在接受促肾上腺皮质激素（ACTH）治疗后大脑中线结构的变化进行了研究，这些结构包括脑桥、小脑蚓部和胼胝体。几乎所有婴儿的这些脑部区域体积均减小。脑桥体积减小被认为与ACTH治疗期间的睡眠障碍密切相关。这些结果可能表明，接受ACTH治疗的婴儿痉挛症患儿惊厥发作停止是由于ACTH对脑干的直接作用。
