Roisman Alejandro, Slavutsky Irma
Laboratorio de Genética de Neoplasias Linfoides; Instituto de Medicina Experimental, CONICET - Academia Nacional de Medicina de Buenos Aires, Argentina.
Medicina (B Aires). 2014;74(2):140-6.
SOX11, belonging to the family of genes SOXC, is a transcript factor involved in the embryonic neurogenesis and tissue remodeling, also participating in the control of cell proliferation. Its role in lymphomagenesis still remains unknown. Recent studies have shown aberrant SOX11 nuclear protein expression as well as mRNA levels in patients with mantle cell lymphoma (MCL). Although the majority of these lymphomas have an aggressive clinical course, there is a subgroup of patients with an indolent clinical evolution, suggesting a greater heterogeneity of this disease. Currently, there are contradictions regarding the association of SOX11 gene expression and outcome in MCL, while some authors have related the lack of SOX11 expression with good prognosis, others find it associated with an adverse clinical course. This difference in the gene expression could be associated to epigenetic mechanisms such as modifications at the histone level and DNA methylation that would allow the aberrant expression of this gene in some lymphoid neoplasias, including LCM. More knowledge of gene SOX11 in LCM will lead to a greater understanding of those mechanisms involved in the pathogenesis and progression of this lymphoma, also the involvement of SOX11 in these processes.
SOX11属于SOXC基因家族，是一种参与胚胎神经发生和组织重塑的转录因子，也参与细胞增殖的调控。其在淋巴瘤发生中的作用仍不清楚。最近的研究表明，套细胞淋巴瘤（MCL）患者中存在SOX11核蛋白表达异常以及mRNA水平异常。尽管这些淋巴瘤大多数具有侵袭性临床病程，但有一部分患者临床进展缓慢，提示该疾病具有更大的异质性。目前，关于SOX11基因表达与MCL预后的关联存在矛盾，一些作者认为SOX11表达缺失与良好预后相关，另一些作者则发现其与不良临床病程相关。这种基因表达的差异可能与表观遗传机制有关，如组蛋白水平修饰和DNA甲基化，这些机制可能导致该基因在包括LCM在内的一些淋巴样肿瘤中异常表达。对LCM中SOX11基因的更多了解将有助于更深入地理解该淋巴瘤发病机制和进展过程中涉及的那些机制，以及SOX11在这些过程中的作用。
