Masini E, Giannella E, Pistelli A, Palmerani B, Gambassi F, Occupati B, Mannaioni P F
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Agents Actions. 1989 Apr;27(1-2):72-4. doi: 10.1007/BF02222202.
In isolated rat serosal mast cells exposed to free radical-generating systems, the release of histamine was associated with a significant increase in malonyldialdehyde (MDA) production suggesting a relationship between histamine release and membrane lipid peroxidation. Under these circumstances, an increase in cytosolic calcium was observed, uncoupled with any stimulation of inositol phospholipid (PtdIns) breakdown. The data suggest similarities between the release of histamine induced by calcium ionophores and by free radical-generating systems.
在暴露于自由基生成系统的离体大鼠浆膜肥大细胞中，组胺的释放与丙二醛（MDA）生成的显著增加相关，提示组胺释放与膜脂质过氧化之间存在关联。在这些情况下，观察到胞质钙增加，且与肌醇磷脂（PtdIns）分解的任何刺激均无关联。数据表明钙离子载体诱导的组胺释放与自由基生成系统诱导的组胺释放之间存在相似性。
