Berberoglu Z, Aktas A, Fidan Y, Canan Yazici A, Aral Y
Department of Endocrinology and Metabolism Ankara Education and Research Hospital Ankara, Turkey -
Minerva Endocrinol. 2014 Jun;39(2):89-97.
We aimed to determine plasma levels of growth differentiation factor (GDF)-15 and their possible association with hormonal and metabolic status as well as echocardiographic profiles and carotid artery intima-media thickness (CAIMT) measurements in patients with polycystic ovary syndrome (PCOS).
Forty-two obese PCOS women aged 25-35 years, 23 women with idiopathic hirsutism and 20 healthy controls matched for age and body mass index were enrolled. Anthropometric, metabolic and hormonal patterns, plasma GDF-15 concentrations, CAIMT, and conventional echocardiographic parameters were measured.
Metabolic/lipid profiles as well as GDF-15 levels were similar across the three groups. CAIMT tended to be higher in PCOS group but did not reach statistical significance. No between-group differences were found in the conventional echocardiographic parameters. Analysis of PCOS patients showed a significant correlation of GDF-15 concentrations with age and homeostasis model assessment (HOMA) index (r=0.319, P<0.05, and r=0.312, P<0.05, respectively). In multiple linear regression analyses, GDF-15 was significantly associated with age (r2=0.102, P<0.05), and HOMA index (r2=0.10, P<0.05).
Plasma GDF-15 levels, CAIMT and conventional echocardiographic parameters in obese subjects with PCOS (25-35 yrs old) were comparable to those in either subjects with idiopathic hirsutism or healthy controls with similar anthropometric and metabolic profiles, suggesting that PCOS alone could not impart an early and higher risk independent of associated risk factors. GDF-15 might provide a link between future diabetes and cardiovascular risk in PCOS women.
我们旨在测定多囊卵巢综合征（PCOS）患者血浆中生长分化因子（GDF）-15的水平，以及它们与激素和代谢状态、超声心动图特征和颈动脉内膜中层厚度（CAIMT）测量值之间的可能关联。
纳入42名年龄在25至35岁之间的肥胖PCOS女性、23名特发性多毛症女性以及20名年龄和体重指数相匹配的健康对照者。测量人体测量学、代谢和激素指标、血浆GDF-15浓度、CAIMT以及传统超声心动图参数。
三组的代谢/脂质谱以及GDF-15水平相似。PCOS组的CAIMT有升高趋势，但未达到统计学显著性。传统超声心动图参数在组间未发现差异。对PCOS患者的分析显示，GDF-15浓度与年龄和稳态模型评估（HOMA）指数显著相关（r = 0.319，P < 0.05；r = 0.312，P < 0.05）。在多元线性回归分析中，GDF-15与年龄（r² = 0.102，P < 0.05）和HOMA指数（r² = 0.10，P < 0.05）显著相关。
肥胖的PCOS患者（25 - 35岁）的血浆GDF-15水平、CAIMT和传统超声心动图参数与特发性多毛症患者或具有相似人体测量学和代谢特征的健康对照者相当，这表明单独的PCOS在不伴有相关危险因素的情况下不会带来早期和更高的风险。GDF-15可能在PCOS女性未来的糖尿病和心血管风险之间提供一种联系。
