钠离子通道的缓慢失活

Slow inactivation of Na(+) channels.

作者信息

Silva Jonathan

机构信息

Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, St. Louis, MO, 63116, USA,

出版信息

Handb Exp Pharmacol. 2014;221:33-49. doi: 10.1007/978-3-642-41588-3_3.

DOI:10.1007/978-3-642-41588-3_3

PMID:24737231

Abstract

Prolonged depolarizing pulses that last seconds to minutes cause slow inactivation of Na(+) channels, which regulates neuron and myocyte excitability by reducing availability of inward current. In neurons, slow inactivation has been linked to memory of previous excitation and in skeletal muscle it ensures myocytes are able to contract when K(+) is elevated. The molecular mechanisms underlying slow inactivation are unclear even though it has been studied for 50+ years. This chapter reviews what is known to date regarding the definition, measurement, and mechanisms of voltage-gated Na(+) channel slow inactivation.

摘要

持续数秒至数分钟的去极化脉冲会导致钠通道的缓慢失活，这通过减少内向电流的可用性来调节神经元和心肌细胞的兴奋性。在神经元中，缓慢失活与先前兴奋的记忆有关，而在骨骼肌中，它确保在钾离子浓度升高时心肌细胞能够收缩。尽管对缓慢失活的研究已超过50年，但其潜在的分子机制仍不清楚。本章回顾了迄今为止关于电压门控钠通道缓慢失活的定义、测量和机制的已知情况。