了解对乙酰氨基酚引起的肝衰竭。 - Suppr

Understanding paracetamol-induced liver failure.

作者信息

Larsen Fin Stolze, Wendon Julia

机构信息

Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, A-2121, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark,

出版信息

Intensive Care Med. 2014 Jun;40(6):888-90. doi: 10.1007/s00134-014-3293-9. Epub 2014 Apr 16.

DOI:10.1007/s00134-014-3293-9

PMID:24737263

Abstract

摘要

相似文献

Understanding paracetamol-induced liver failure.了解对乙酰氨基酚引起的肝衰竭。

Intensive Care Med. 2014 Jun;40(6):888-90. doi: 10.1007/s00134-014-3293-9. Epub 2014 Apr 16.

[Acetaminophen and the liver].[对乙酰氨基酚与肝脏]

Rev Esp Enferm Dig. 2011 May;103(5):275.

[Fulminant hepatitis after a therapeutic dose of acetaminophen in a chronic alcoholic patient].[一名慢性酒精性肝病患者服用治疗剂量对乙酰氨基酚后发生暴发性肝炎]

Rev Med Interne. 2004 Mar;25(3):251-2. doi: 10.1016/j.revmed.2003.12.011.

Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity.针对对乙酰氨基酚（扑热息痛）肝毒性的新型疗法

EBioMedicine. 2019 Aug;46:9-10. doi: 10.1016/j.ebiom.2019.07.054. Epub 2019 Jul 23.

Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report.妊娠急性脂肪肝及对乙酰氨基酚中毒导致肝衰竭并进行产后肝移植。病例报告。

J Reprod Med. 2002 Jul;47(7):584-6.

Liver failure cases fall after US clampdown on paracetamol.美国加强对乙酰氨基酚管控后，肝衰竭病例减少。

Nature. 2023 Mar;615(7952):377. doi: 10.1038/d41586-023-00622-z.

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity.食物源性抗氧化剂在对乙酰氨基酚诱导的肝毒性中的作用。

Pharm Biol. 2016 Oct;54(10):2340-52. doi: 10.3109/13880209.2016.1150302. Epub 2016 Mar 9.

Acetaminophen-induced hepatotoxicity: predisposing factors and treatments.对乙酰氨基酚诱导的肝毒性：易感因素与治疗方法

Adv Intern Med. 1997;42:453-83.

Acetaminophen-related hepatotoxicity.对乙酰氨基酚相关的肝毒性。

Clin Liver Dis. 2013 Nov;17(4):587-607, viii. doi: 10.1016/j.cld.2013.07.005. Epub 2013 Sep 4.

Paracetamol-induced fulminant hepatic failure in a child after 5 days of therapeutic doses.一名儿童在接受治疗剂量的扑热息痛5天后发生暴发性肝衰竭。

Paediatr Anaesth. 2000;10(3):344-5. doi: 10.1046/j.1460-9592.2000.00515.x.

引用本文的文献

Gallic Acid Alleviates Acetaminophen-Induced Acute Liver Injury by Regulating Inflammatory and Oxidative Stress Signaling Proteins.没食子酸通过调节炎症和氧化应激信号蛋白减轻对乙酰氨基酚诱导的急性肝损伤。

Antioxidants (Basel). 2025 Jul 14;14(7):860. doi: 10.3390/antiox14070860.

Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2.几丁质酶3样蛋白1缺乏通过脂钙蛋白-2抑制中性粒细胞募集来改善药物诱导的急性肝损伤。

Front Pharmacol. 2025 Mar 24;16:1548832. doi: 10.3389/fphar.2025.1548832. eCollection 2025.

Natural Polyphenol-Mediated Inhibition of Ferroptosis Alleviates Oxidative Damage and Inflammation in Acute Liver Injury.天然多酚介导的铁死亡抑制减轻急性肝损伤中的氧化损伤和炎症。

Biomater Res. 2025 Mar 18;29:0167. doi: 10.34133/bmr.0167. eCollection 2025.

Prenatal cigarette smoke exposure sensitizes acetaminophen-induced liver injury by modulating miR-34a-5p in male offspring mice.产前暴露于香烟烟雾通过调节雄性子代小鼠中的miR-34a-5p使对乙酰氨基酚诱导的肝损伤敏感化。

Front Cell Dev Biol. 2024 Jul 30;12:1393618. doi: 10.3389/fcell.2024.1393618. eCollection 2024.

Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice.中性粒细胞弹性蛋白酶在 BALB/c 小鼠急性对乙酰氨基酚肝毒性中的重要作用。

Int J Mol Sci. 2023 Apr 25;24(9):7845. doi: 10.3390/ijms24097845.

The progress to establish optimal animal models for the study of acute-on-chronic liver failure.建立用于急性慢性肝衰竭研究的最佳动物模型的进展。

Front Med (Lausanne). 2023 Feb 9;10:1087274. doi: 10.3389/fmed.2023.1087274. eCollection 2023.

Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.芍药苷通过 JNK 信号通路保护小鼠对乙酰氨基酚诱导的肝损伤。

Molecules. 2022 Dec 4;27(23):8534. doi: 10.3390/molecules27238534.

Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress.甘草酸通过PKM2调节氧化应激减轻雷公藤多苷片诱导的急性肝损伤

Metabolites. 2022 Nov 17;12(11):1128. doi: 10.3390/metabo12111128.

Corilagin reduces acetaminophen-induced hepatotoxicity through MAPK and NF-B signaling pathway in a mouse model.在小鼠模型中，柯里拉京通过丝裂原活化蛋白激酶（MAPK）和核因子-κB（NF-κB）信号通路减轻对乙酰氨基酚诱导的肝毒性。

Am J Transl Res. 2020 Sep 15;12(9):5597-5607. eCollection 2020.

ORY supplementation mitigates acetaminophen-induced acute liver failure in male mice: role of oxidative stress and apoptotic markers.ORY 补充剂可减轻雄性小鼠的对乙酰氨基酚诱导的急性肝衰竭：氧化应激和凋亡标志物的作用。

Naunyn Schmiedebergs Arch Pharmacol. 2020 Nov;393(11):2129-2137. doi: 10.1007/s00210-020-01930-1. Epub 2020 Jun 29.

本文引用的文献

Acute liver failure.急性肝衰竭

N Engl J Med. 2013 Dec 26;369(26):2525-34. doi: 10.1056/NEJMra1208937.

Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure.分泌白细胞蛋白酶抑制剂：对乙酰氨基酚诱导的急性肝衰竭抗炎反应的关键介质。

Hepatology. 2014 Apr;59(4):1564-76. doi: 10.1002/hep.26933. Epub 2014 Feb 28.

Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF).肝硬化患者因肝性脑病住院的特征、风险因素和死亡率，伴有和不伴有慢加急性肝衰竭（ACLF）。

J Hepatol. 2014 Feb;60(2):275-81. doi: 10.1016/j.jhep.2013.10.004. Epub 2013 Oct 12.

Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial.白蛋白透析联合非细胞型人工肝支持系统治疗急性肝衰竭患者的随机对照研究。

Ann Intern Med. 2013 Oct 15;159(8):522-31. doi: 10.7326/0003-4819-159-8-201310150-00005.

The neurological manifestations of acute liver failure.急性肝衰竭的神经表现。

Neurochem Int. 2012 Jun;60(7):662-71. doi: 10.1016/j.neuint.2011.10.006. Epub 2011 Nov 2.

Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography.血栓弹力描记术评估急性肝损伤/急性肝衰竭对止血功能的影响极小。

J Hepatol. 2012 Jan;56(1):129-36. doi: 10.1016/j.jhep.2011.04.020. Epub 2011 May 19.

The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies.肝移植在急性肝衰竭治疗中的应用：对乙酰氨基酚与非对乙酰氨基酚病因的比较

Liver Transpl. 2009 Jun;15(6):600-9. doi: 10.1002/lt.21681.

Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis.使用非处方镇痛药与肝硬化患者的急性失代偿无关。

Clin Gastroenterol Hepatol. 2009 Sep;7(9):994-9; quiz 913-4. doi: 10.1016/j.cgh.2009.04.015. Epub 2009 Apr 24.

Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.对乙酰氨基酚所致急性肝衰竭患者高乳酸血症、多器官功能衰竭及全身炎症反应综合征的预后影响

Crit Care Med. 2006 Feb;34(2):337-43. doi: 10.1097/01.ccm.0000194724.70031.b6.

Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial.分子吸附循环系统治疗超急性肝衰竭患者的全身血流动力学效应：一项前瞻性对照试验。

Liver Transpl. 2003 Mar;9(3):290-7. doi: 10.1053/jlts.2003.50051.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Understanding paracetamol-induced liver failure.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献