Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity.
作者信息
Jaeschke Hartmut
机构信息
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA.
出版信息
EBioMedicine. 2019 Aug;46:9-10. doi: 10.1016/j.ebiom.2019.07.054. Epub 2019 Jul 23.
Abstract
摘要
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Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial).随机、开放标签、探索性、安全性和耐受性研究的主要结果，该研究在接受扑热息痛过量的 N-乙酰半胱氨酸 12 小时方案治疗的患者中使用了甘氨酰胺膦酸（calmangafodipir）（POP 试验）。
EBioMedicine. 2019 Aug;46:423-430. doi: 10.1016/j.ebiom.2019.07.013. Epub 2019 Jul 13.
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Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.对乙酰氨基酚过量使用后使用机制生物标志物进行危险分层：两项前瞻性队列研究的结果。
Lancet Gastroenterol Hepatol. 2018 Feb;3(2):104-113. doi: 10.1016/S2468-1253(17)30266-2. Epub 2017 Nov 14.
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