牛γ球蛋白诱导的迟发型超敏反应豚鼠皮肤损伤中脯氨酰内肽酶活性的降低
Depression of prolylendopeptidase activity in the delayed hypersensitive guinea pig skin lesion induced by bovine gamma-globulin.
作者信息
Shoji S, Imazumi K, Yamaoka T, Funakoshi T, Tanaka J, Kambara T, Ueki H, Kubota Y
机构信息
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
出版信息
Biochem Int. 1989 Jun;18(6):1183-92.
Prolylendopeptidase activity was increasingly depressed with time from 6 to 24 hr after the start of sensitization in the delayed hypersensitive guinea pig skin lesion induced by bovine gamma-globulin as an antigen. The remarkably depressed activity of the enzyme in the violently inflamed skin began to be restored slowly 48 hr after sensitization, and its activity was ultimately recovered to the original level by 504 hr after a single sensitization in vivo. Depression of the enzymatic activity is caused by a novel prolyendopeptidase inhibitor, whose amino acid composition is 7 Glu, 1 Ser, 2 Gly, 1 Ala, 2 Pro, and 1 Val, generated by inflammation.
在用牛γ球蛋白作为抗原诱导的迟发型超敏豚鼠皮肤损伤中，从致敏开始6至24小时，脯氨酰内肽酶活性随时间逐渐降低。在剧烈炎症皮肤中，该酶活性显著降低，致敏48小时后开始缓慢恢复，在体内单次致敏504小时后其活性最终恢复到原始水平。酶活性的降低是由一种新型脯氨酰内肽酶抑制剂引起的，该抑制剂由炎症产生，其氨基酸组成为7个谷氨酸、1个丝氨酸、2个甘氨酸、1个丙氨酸、2个脯氨酸和1个缬氨酸。
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