Zhang Long Jiang, Qi Li, Wang Jing, Tang Chun Xiang, Zhou Chang Sheng, Ji Xue Man, Spearman James V, De Cecco Carlo Nicola, Meinel Felix G, Schoepf U Joseph, Lu Guang Ming
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China,
Eur Radiol. 2014 Jul;24(7):1537-46. doi: 10.1007/s00330-014-3157-2. Epub 2014 Apr 16.
To evaluate the feasibility, image quality and radiation dose of prospectively ECG-triggered high-pitch coronary CT angiography (CCTA) with 30 mL contrast agent at 70 kVp.
Fifty-eight patients with suspected coronary artery disease, a body mass index (BMI) of less than 25 kg/m(2), sinus rhythm and a heart rate (HR) of less than 70 beats per minute (bpm) were prospectively enrolled in this study. Thirty mL of 370 mg I/mL iodinated contrast agent was administrated at a flow rate of 5 mL/s. All patients underwent prospectively ECG-triggered high-pitch CCTA on a second-generation dual-source CT system at 70 kVp using automated tube current modulation.
Fifty-six patients (96.6%) had diagnostic CCTA images and two patients (3.4%) had one vessel with poor image quality each rated as non-diagnostic. No significant effects of HR, HR variability and BMI on CCTA image quality were observed (all P > 0.05). Effective dose was 0.17 ± 0.02 mSv and the size-specific dose estimate was 1.03 ± 0.13 mGy.
Prospectively ECG-triggered high-pitch CCTA at 70 kVp with 30 mL of contrast agent can provide diagnostic image quality at a radiation dose of less than 0.2 mSv in patients with a BMI of less than 25 kg/m(2) and an HR of less than 70 bpm.
• Prospectively ECG-triggered high-pitch CCTA at 70 kVp/30 mL contrast agent is feasible. • Diagnostic image quality can be obtained at a radiation dose of less than 0.2 mSv. • This protocol is suitable for normal-weight patients with slow heart rate.
评估在70 kVp管电压下使用30 mL造影剂进行前瞻性心电图触发的高螺距冠状动脉CT血管造影（CCTA）的可行性、图像质量和辐射剂量。
前瞻性纳入58例疑似冠心病患者，其体重指数（BMI）小于25 kg/m²，窦性心律，心率（HR）小于70次/分钟（bpm）。以5 mL/s的流率注射30 mL浓度为370 mg I/mL的碘化造影剂。所有患者在第二代双源CT系统上于70 kVp管电压下采用自动管电流调制技术进行前瞻性心电图触发的高螺距CCTA检查。
56例患者（96.6%）获得了诊断性CCTA图像，2例患者（3.4%）有1支血管图像质量差，被判定为非诊断性。未观察到HR、HR变异性和BMI对CCTA图像质量有显著影响（所有P>0.05）。有效剂量为0.17±0.02 mSv，大小特异性剂量估计值为1.03±0.13 mGy。
对于BMI小于25 kg/m²且HR小于70 bpm的患者，在70 kVp管电压下使用30 mL造影剂进行前瞻性心电图触发的高螺距CCTA检查可在小于0.2 mSv的辐射剂量下提供诊断性图像质量。
• 在70 kVp管电压下使用30 mL造影剂进行前瞻性心电图触发的高螺距CCTA检查是可行的。• 在小于0.2 mSv的辐射剂量下可获得诊断性图像质量。• 该方案适用于心率较慢的正常体重患者。
