Zhang Xiaoyan, Zhang Yun, Nie Yunqiang, Wang Shoufeng, Chen Yanlin, Sun Dezhong
Department of Medicine Oncology, Linyi City People's Hospital, Linyi, 276000, China.
Tumour Biol. 2014 Jul;35(7):6879-86. doi: 10.1007/s13277-014-1940-y. Epub 2014 Apr 16.
The diagnosis of nasopharyngeal cancer (NPC) remains a clinical challenge. Many studies have assessed the diagnostic potential of Zta antibody of the Epstein-Barr virus (EBV) in NPC patients but with controversial results. This study aims to summarize the overall diagnostic performance of EBV Zta antibody in NPC. Based on a comprehensive search of the Pubmed and Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang Databases and China Citation Databases, we identified outcome data from all articles estimating diagnostic accuracy of EBV Zta antibody for NPC. A summary estimation for sensitivity, specificity, and other diagnostic indexes were pooled using a bivariate model. The overall measure of accuracy was calculated using summary receiver operating characteristic curve and the area under curve (AUC) was calculated. According to our inclusion criteria, 17 studies with 11,822 subjects (1,645 NPC cases, 10,177 controls) were included. The summary estimates were: sensitivity 0.87 (95 % confidence interval [CI] = 0.86-0.89), specificity 0.94 (95 % CI = 0.93-0.94), positive likelihood ratio 8.05 (95 % CI = 5.59-11.59), negative likelihood ratio 0.16 (95 % CI = 0.12-0.21), diagnostic odds ratio 52.93 (95 % CI = 29.95-93.56), the AUC and Q* index were 0.9352 and 0.8714, respectively. In conclusion, serum EBV Zta had a better diagnostic performance for NPC. Further studies should be performed to confirm our findings.
鼻咽癌（NPC）的诊断仍然是一项临床挑战。许多研究评估了爱泼斯坦-巴尔病毒（EBV）Zta抗体在NPC患者中的诊断潜力，但结果存在争议。本研究旨在总结EBV Zta抗体在NPC中的总体诊断性能。通过全面检索PubMed、Embase、Web of Science、中国知网（CNKI）、万方数据库和中国引文数据库，我们从所有评估EBV Zta抗体对NPC诊断准确性的文章中确定了结果数据。使用双变量模型汇总敏感性、特异性和其他诊断指标的汇总估计值。使用汇总的受试者工作特征曲线计算总体准确性指标，并计算曲线下面积（AUC）。根据我们的纳入标准，纳入了17项研究，共11822名受试者（1645例NPC病例，10177例对照）。汇总估计值为：敏感性0.87（95%置信区间[CI]=0.86-0.89），特异性0.94（95%CI=0.93-0.94），阳性似然比8.05（95%CI=5.59-11.59），阴性似然比0.16（95%CI=0.12-0.21），诊断比值比52.93（95%CI=29.95-93.56），AUC和Q*指数分别为0.9352和0.8714。总之，血清EBV Zta对NPC具有较好的诊断性能。应进行进一步研究以证实我们的发现。
