Zając Adam, Wilk Michał, Socha Teresa, Maszczyk Adam, Chycki Jakub
Department of Sports Theory, Academy of Physical Education, Katowice, Poland.
Department of Sports Training, Academy of Physical Education, Katowice, Poland.
Ann Agric Environ Med. 2014;21(1):156-60.
Andropause and aging are associated with neuroendocrine dysfunctions. Growth hormone and testosterone play a significant role in several processes affecting adaptation and thereby also everyday functioning. The aim of this research project was to evaluate the effects of recombinant human growth hormone and testosterone enanthate injections on body mass and body composition, aerobic and anaerobic fitness and lipid profile in middle-aged men.
The research group was comprised of 14 men aged 45 - 60 years. Two series of laboratory analyses were performed. Independent tests were carried out at baseline and after 12 weeks of the experiment. The data were analyzed using Statistica 9.1 software.
A two-way repeated measures ANOVA revealed a statistically significant effect of the intervention programme on fat-free mass (η(2)=0.34), total body fat (η(2)=0.79), total cholesterol (η(2)=0.30), high-density lipoprotein cholesterol (η(2)=0.31), low-density lipoprotein cholesterol (η(2)=0.42), triglyceride (η(2)=0.28), testosterone (η(2)=0.52), insulin-like growth factor 1 (η(2)=0.47) and growth hormone (η(2)=0.63). Furthermore, ANOVA revealed a statistically significant effect of the rhGH and T treatment on maximal oxygen uptake (η(2)=0.63), anaerobic threshold (η(2)=0.61) and maximal work rate (η(2)=0.53).
It should be emphasized that the lipid profile was affected not only by rhGH+T replacement therapy, but also by the prescribed physical activity programme. The strength and endurance fitness programme alone did not cause significant changes in body mass and composition, nor the anaerobic and aerobic capacity. On the other hand, the rhGH=T treatment stimulated these changes significantly.
男性更年期和衰老与神经内分泌功能障碍有关。生长激素和睾酮在影响适应能力进而影响日常功能的多个过程中发挥着重要作用。本研究项目的目的是评估重组人生长激素和庚酸睾酮注射对中年男性体重、身体成分、有氧和无氧适能以及血脂谱的影响。
研究组由14名年龄在45至60岁之间的男性组成。进行了两轮实验室分析。在基线和实验12周后进行了独立测试。使用Statistica 9.1软件对数据进行分析。
双向重复测量方差分析显示，干预方案对去脂体重（η(2)=0.34）、全身脂肪（η(2)=0.79）、总胆固醇（η(2)=0.30）、高密度脂蛋白胆固醇（η(2)=0.31）、低密度脂蛋白胆固醇（η(2)=0.42）、甘油三酯（η(2)=0.28）、睾酮（η(2)=0.52）、胰岛素样生长因子1（η(2)=0.47）和生长激素（η(2)=0.63）有统计学显著影响。此外，方差分析显示，重组人生长激素和睾酮治疗对最大摄氧量（η(2)=0.63）、无氧阈值（η(2)=0.61）和最大工作率（η(2)=0.53）有统计学显著影响。
应该强调的是，血脂谱不仅受到重组人生长激素+睾酮替代疗法的影响，还受到规定的体育活动方案的影响。仅力量和耐力适能方案不会导致体重和身体成分、无氧和有氧能力发生显著变化。另一方面，重组人生长激素=睾酮治疗显著刺激了这些变化。
