Jakiel Grzegorz, Makara-Studzińska Marta, Ciebiera Michał, Słabuszewska-Jóźwiak Aneta
I Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Applied Psychology, II Faculty of Medicine with English Language Division, Medical University of Lublin, Lublin, Poland.
Prz Menopauzalny. 2015 Mar;14(1):1-6. doi: 10.5114/pm.2015.49998. Epub 2015 Mar 25.
The term 'male menopause' was first used in 1944 to describe various complaints of ageing men which at least partially mirrored the climacteric symptoms in women. Continuous research resulted in the evolution of opinions about the nature of these complaints, from the clinical syndrome, diagnosed with the use of disease-targeted questionnaires, to a well-defined clinical and biochemical syndrome. The pathophysiological causes - gonad ageing (with a compensatory rise in luteinizing hormone), age-related increase in serum sex hormone-binding globulin (SHBG) levels, the role of visceral adipose tissue as a place for aromatization of androgen to estrogen, and lower sensitivity of testosterone receptors - have been described. However, no consensus was reached as far as the definition, incidence, treatment, and especially testosterone therapy, are concerned. Our review presents the current standpoints, indicating the predictive role of late-onset hypogonadism (LOH) in evaluating male health as well as the current literature reports on the risks and benefits of using testosterone therapy.
“男性更年期”一词于1944年首次被用于描述老年男性的各种不适症状，这些症状至少部分反映了女性更年期的症状。持续的研究使得人们对这些不适症状本质的看法不断演变，从通过针对疾病的问卷诊断出的临床综合征，发展到明确界定的临床和生化综合征。其病理生理原因已被描述，包括性腺衰老（伴有黄体生成素的代偿性升高）、血清性激素结合球蛋白（SHBG）水平随年龄增长而升高、内脏脂肪组织作为雄激素向雌激素芳香化场所的作用以及睾酮受体敏感性降低。然而，在定义、发病率、治疗，尤其是睾酮治疗方面，尚未达成共识。我们的综述呈现了当前的观点，指出迟发性性腺功能减退（LOH）在评估男性健康中的预测作用，以及当前关于使用睾酮治疗的风险和益处的文献报道。
