Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family.

BACKGROUND

Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types.

METHODS

HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction.

RESULTS

Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA10501, HLA DQB10302, and HLA DRB111 alleles were common in all family members. HLA DRB104 was detected in three of them.

CONCLUSION

This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.