Kraus I, Lehnert M, Pristautz H, Sixl B, Krejs G J
III. Medizinische Abteilung, Universität Graz.
Dtsch Med Wochenschr. 1989 Aug 4;114(31-32):1207-9. doi: 10.1055/s-2008-1066742.
A diagnostic laparotomy was performed on a 41-year old woman who, having suffered from recurrent arthralgias for several years and intermittent fever for many months, was found to have extensive enlargement of abdominal lymph-nodes, raising the suspicion of malignant lymphoma. Frozen-tissue biopsy was highly suspicious of Hodgkin's lymphoma, but light- and electron-microscopy revealed Whipple's disease, confirmed in an endoscopically obtained duodenal mucosal biopsy. The arthralgia quickly responded to antibiotic treatment. This case demonstrates the potential difficulties and errors in the diagnosis of Whipple's disease.
对一名41岁女性进行了诊断性剖腹术。该女性多年来反复出现关节痛，数月来间歇性发热，发现腹部淋巴结广泛肿大，怀疑患有恶性淋巴瘤。冰冻组织活检高度怀疑为霍奇金淋巴瘤，但光镜和电镜检查显示为惠普尔病，内镜获取的十二指肠黏膜活检得以证实。关节痛对抗生素治疗迅速产生反应。该病例表明了惠普尔病诊断中可能存在的困难和错误。
