Tilghman S M, Belayew A
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5254-7. doi: 10.1073/pnas.79.17.5254.
The ontogeny of expression of the alpha-fetoprotein (AFP) and albumin genes was examined in livers from late prenatal to 1-month-postpartum C3H/He mice. A parallel accumulation of both AFP and albumin mRNAs before birth, followed by a selective nonreciprocal decrease in AFP mRNA after birth, was observed. The decrease in AFP mRNA was the result of a decrease in transcription of the AFP gene, as measured by an in vitro nuclear transcription assay. We suggest a model for hepatic expression of the AFP and albumin gene cluster in which transcription of the two genes is activated simultaneously during differentiation and each gene is thereafter modulated independently in committed cells.
研究了产前晚期至产后1个月的C3H/He小鼠肝脏中甲胎蛋白（AFP）和白蛋白基因表达的个体发生情况。观察到出生前AFP和白蛋白mRNA平行积累，出生后AFP mRNA选择性非相互性减少。通过体外细胞核转录试验测定，AFP mRNA的减少是AFP基因转录减少的结果。我们提出了一个AFP和白蛋白基因簇肝脏表达模型，其中两个基因的转录在分化过程中同时被激活，此后每个基因在定向细胞中独立调节。
