Kansal Vinay, Patriciu Iulia, Kiang Michael
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
St. Joseph's Healthcare, Hamilton, Ontario L8N 3K7, Canada.
Schizophr Res. 2014 Jun;156(1):122-7. doi: 10.1016/j.schres.2014.03.023. Epub 2014 Apr 13.
Impaired illness insight in schizophrenia is associated with non-adherence and worse outcomes. Schizophrenia patients also exhibit error-monitoring deficits, which have been proposed to cause poor insight. To test this hypothesis, we examined whether schizophrenia patients' deficits in neurophysiological error-monitoring indices, the error-related negativity (ERN) and error positivity (Pe) event-related potential (ERP) amplitudes, are associated with impaired insight. ERPs were recorded in 18 schizophrenia patients and 18 normal comparison participants during a Stroop task. Patients' subnormal ERN and Pe amplitudes did not correlate with insight, suggesting that impaired insight in schizophrenia stems from neurocognitive mechanisms other than deficient error monitoring.
精神分裂症患者的疾病洞察力受损与治疗依从性差及预后不良有关。精神分裂症患者还表现出错误监测缺陷，有人认为这会导致洞察力差。为了验证这一假设，我们研究了精神分裂症患者在神经生理错误监测指标、错误相关负波（ERN）和错误正波（Pe）事件相关电位（ERP）波幅方面的缺陷是否与洞察力受损有关。在一项Stroop任务中，记录了18名精神分裂症患者和18名正常对照参与者的ERP。患者低于正常水平的ERN和Pe波幅与洞察力无关，这表明精神分裂症患者的洞察力受损源于错误监测不足以外的神经认知机制。
