撒哈拉以南非洲地区用于诊断与艾滋病毒相关的结核病的血清学检测方法？
Serological diagnostic assays for HIV-associated tuberculosis in sub-Saharan Africa?
作者信息
Lawn Stephen D
机构信息
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, and The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
出版信息
Clin Vaccine Immunol. 2014 Jun;21(6):787-90. doi: 10.1128/CVI.00201-14. Epub 2014 Apr 16.
In this issue of Clinical and Vaccine Immunology, Siev and colleagues present an evaluation of antibody responses to four immunodominant proteins of Mycobacterium tuberculosis in patients with HIV-associated pulmonary tuberculosis (TB) in South Africa (M. Siev, D. Wilson, S. Kainth, V. O. Kasprowicz, C. M. Feintuch, E. Jenny-Avital, and J. J. Achkar, 21:791-798, 2014, doi:http://dx.doi.org/10.1128/CVI.00805-13). This commentary discusses the enormous need for simple point-of-care assays for tuberculosis (TB) diagnosis in patients with and without HIV coinfection in high-burden settings and considers the potential role of serological assays and the huge challenges inherent in developing and validating such assays.
在本期《临床与疫苗免疫学》中，西夫及其同事对南非HIV相关肺结核（TB）患者针对结核分枝杆菌四种免疫显性蛋白的抗体反应进行了评估（M. 西夫、D. 威尔逊、S. 凯恩思、V. O. 卡斯普罗维茨、C. M. 费因图赫、E. 珍妮 - 阿维塔尔和J. J. 阿查尔，2014年，21:791 - 798，doi:http://dx.doi.org/10.1128/CVI.00805 - 13）。本述评讨论了在高负担环境中，对于合并或未合并HIV感染的患者进行结核病（TB）诊断的简单即时检测方法的迫切需求，并考虑了血清学检测的潜在作用以及开发和验证此类检测方法所固有的巨大挑战。
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