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本文引用的文献

1
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation. chimpanzee 腺病毒-MVA 免疫诱导的对人疟疾的保护性 CD8+ T 细胞免疫。
Nat Commun. 2013;4:2836. doi: 10.1038/ncomms3836.
2
A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity.一种新型低人血清流行率的黑猩猩腺病毒载体：改进的载体衍生系统和比较免疫原性。
PLoS One. 2012;7(7):e40385. doi: 10.1371/journal.pone.0040385. Epub 2012 Jul 13.
3
Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector.临床评估重组猿猴腺病毒 ChAd63：一种有效的新型疫苗载体。
J Infect Dis. 2012 Mar 1;205(5):772-81. doi: 10.1093/infdis/jir850. Epub 2012 Jan 24.
4
Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.来源于大量猿猴腺病毒的疫苗载体在多种物种中诱导强烈的细胞免疫。
Sci Transl Med. 2012 Jan 4;4(115):115ra2. doi: 10.1126/scitranslmed.3002925.
5
Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.新型腺病毒疫苗可诱导人体对 HCV 产生广泛而持久的 T 细胞应答。
Sci Transl Med. 2012 Jan 4;4(115):115ra1. doi: 10.1126/scitranslmed.3003155.
6
Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors.恶性疟原虫血期抗原 MSP1 在 ChAd63 和 MVA 疫苗载体中的 I 期临床评估。
Mol Ther. 2011 Dec;19(12):2269-76. doi: 10.1038/mt.2011.176. Epub 2011 Aug 23.
7
Neutralizing antibodies to human and simian adenoviruses in humans and New-World monkeys.人体和新世界猴体内针对人腺病毒和猴腺病毒的中和抗体。
Virology. 2010 Nov 10;407(1):1-6. doi: 10.1016/j.virol.2010.07.043. Epub 2010 Aug 24.
8
Prevalence of serum neutralizing antibodies against chimpanzee adenovirus 63 and human adenovirus 5 in Kenyan children, in the context of vaccine vector efficacy.在疫苗载体效力背景下，肯尼亚儿童中针对黑猩猩腺病毒63型和人腺病毒5型的血清中和抗体流行情况。
Vaccine. 2009 Jun 2;27(27):3501-4. doi: 10.1016/j.vaccine.2009.03.080. Epub 2009 Apr 16.
9
Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei.猿猴腺病毒载体对伯氏疟原虫的单剂量免疫原性和保护效力
Eur J Immunol. 2008 Mar;38(3):732-41. doi: 10.1002/eji.200737672.
10
Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa.撒哈拉以南非洲地区个体中腺病毒特异性中和抗体滴度的年龄依赖性
J Clin Microbiol. 2006 Oct;44(10):3781-3. doi: 10.1128/JCM.01249-06.

在评估基于病毒载体的候选疟疾疫苗方案之前，对黑猩猩腺病毒63型中和抗体进行评估。

Assessment of chimpanzee adenovirus serotype 63 neutralizing antibodies prior to evaluation of a candidate malaria vaccine regimen based on viral vectors.

作者信息

Nébié Issa, Edwards Nick J, Tiono Alfred B, Ewer Katie J, Sanou Guillaume S, Soulama Issiaka, Sanon Souleymane, Diarra Amidou, Yaro Jean Baptiste, Kangoye David, Imoukhuede Egeruan B, Hill Adrian V S, Sirima Sodiomon B

机构信息

Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso

Centre for Clinical Vaccinology and Tropical Medicine and the Jenner Institute Laboratories, University of Oxford, Oxford, United Kingdom.

出版信息

Clin Vaccine Immunol. 2014 Jun;21(6):901-3. doi: 10.1128/CVI.00723-13. Epub 2014 Apr 16.

DOI:10.1128/CVI.00723-13
PMID:24739980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4054245/
Abstract

Prior to a chimpanzee adenovirus-based (ChAd63) malarial vaccine trial, sera were collected to assess ChAd63-specific neutralizing antibody titers in Banfora (Burkina Faso). The low neutralizing antibody titers reported in both adults and children (median titers, 139.1 and 35.0, respectively) are encouraging for the potential use of ChAd63 as a malarial vaccine vector.

摘要

在一项基于黑猩猩腺病毒（ChAd63）的疟疾疫苗试验之前，采集了血清以评估布基纳法索班福拉地区针对ChAd63的中和抗体滴度。成人和儿童中报告的低中和抗体滴度（中位数滴度分别为139.1和35.0）对于ChAd63作为疟疾疫苗载体的潜在用途而言是令人鼓舞的。