In vitro pemphigus vulgaris model using organotypic cultures of human epidermal keratinocytes.
作者信息
Hunziker T, Boillat C, Gerber H A, Wiesmann U, Wintroub B U
机构信息
Department of Dermatology, University of Berne, Switzerland.
出版信息
J Invest Dermatol. 1989 Aug;93(2):263-7. doi: 10.1111/1523-1747.ep12277586.
PMID:2474033
Abstract
Using the Combi-ring-dish (CRD), a new culture device, organotypic cultures of human epidermal keratinocytes were grown on bovine eye lens capsules. In these highly differentiated cultures, typical suprabasal acantholysis was induced by pemphigus vulgaris antibodies. This in vitro pemphigus vulgaris model may be used to analyse keratinocyte-derived factors causing acantholysis in experimental pemphigus.
摘要
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