Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4.
J Neurosci. 2014 Apr 16;34(16):5431-46. doi: 10.1523/JNEUROSCI.0511-14.2014.
Navigation requires coordination of egocentric and allocentric spatial reference frames and may involve vectorial computations relative to landmarks. Creation of a representation of target heading relative to landmarks could be accomplished from neurons that encode the conjunction of egocentric landmark bearings with allocentric head direction. Landmark vector representations could then be created by combining these cells with distance encoding cells. Landmark vector cells have been identified in rodent hippocampus. Given remembered vectors at goal locations, it would be possible to use such cells to compute trajectories to hidden goals. To look for the first stage in this process, we assessed parietal cortical neural activity as a function of egocentric cue light location and allocentric head direction in rats running a random sequence to light locations around a circular platform. We identified cells that exhibit the predicted egocentric-by-allocentric conjunctive characteristics and anticipate orienting toward the goal.
导航需要协调自我中心和客体中心的空间参照系，并且可能涉及相对于地标物的向量计算。相对于地标物的目标朝向的表示可以通过编码自我中心地标方位与客体中心头部方向的结合的神经元来创建。然后可以通过将这些细胞与距离编码细胞结合来创建地标向量表示。地标向量细胞已在啮齿动物海马体中被识别。给定目标位置的记忆向量，就有可能使用这些细胞来计算到隐藏目标的轨迹。为了寻找这个过程的第一阶段，我们评估了在大鼠随机跑到圆形平台周围的灯光位置时，顶叶皮层神经活动作为自我中心提示灯位置和客体中心头部方向的函数。我们识别出表现出预测的自我中心-客体中心联合特征的细胞，并预期其朝向目标。
