Markus Amos, Waldman Ben-Asher Hiba, Kinchington Paul R, Goldstein Ronald S
Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Departments of Ophthalmology, Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Virol. 2014 Jul;88(13):7674-7. doi: 10.1128/JVI.00500-14. Epub 2014 Apr 16.
Transcriptional changes following varicella-zoster virus (VZV) infection of cultured human neurons derived from embryonic stem cells were compared to those in VZV-infected human foreskin fibroblasts. Transcription of 340 neuronal genes significantly altered by VZV infection included 223 transcript changes unique to neurons. Strikingly, genes inhibiting apoptosis were upregulated in neurons, while proapoptotic gene transcription was increased in fibroblasts. These data are a basis for discovery of differences in virus-host interactions between these VZV targets.
将源自胚胎干细胞的培养人神经元感染水痘带状疱疹病毒（VZV）后的转录变化与VZV感染的人包皮成纤维细胞中的转录变化进行了比较。VZV感染显著改变的340个神经元基因的转录中，有223个转录变化是神经元特有的。引人注目的是，抑制凋亡的基因在神经元中上调，而促凋亡基因转录在成纤维细胞中增加。这些数据为发现这些VZV靶标之间病毒-宿主相互作用的差异奠定了基础。
