Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, 314 Schultz Laboratory, Princeton, NJ 08544, USA.
J Neuroimmune Pharmacol. 2010 Sep;5(3):418-27. doi: 10.1007/s11481-010-9212-0. Epub 2010 Apr 17.
Alphaherpesviruses are a subfamily of the Herpesviridae that can invade the nervous system and establish either lytic or latent infections. The establishment of latent infection can occur only in neurons, indicating a unique virus-host interaction in these cells. Here, we compare results from seven microarray studies that focused on the host response of either neural tissue or isolated neurons to alphaherpesvirus infection. These studies utilized either herpes simplex virus type 1 or pseudorabies virus as the infectious agent. From these data, we have found common host responses spanning a variety of infection models in different species, with different herpesvirus strains, and during all phases of infection including lytic, latent, and reactivation. The repeated observation of transcriptional effects on these genes and gene families indicates their likely importance in host defenses or the viral infectious process. We discuss the possible role of these different genes and genes families in alphaherpesvirus infection.
α疱疹病毒是疱疹病毒科的一个亚科，可侵入神经系统并建立裂解或潜伏感染。潜伏感染的建立只能发生在神经元中，这表明这些细胞中的病毒-宿主相互作用具有独特性。在这里，我们比较了七项专注于神经组织或分离神经元对α疱疹病毒感染的宿主反应的微阵列研究的结果。这些研究使用单纯疱疹病毒 1 型或伪狂犬病病毒作为感染剂。从这些数据中，我们发现了跨越不同物种、不同疱疹病毒株以及感染的所有阶段（包括裂解、潜伏和再激活）的常见宿主反应。对这些基因和基因家族的转录效应的反复观察表明，它们在宿主防御或病毒感染过程中可能具有重要作用。我们讨论了这些不同的基因和基因家族在α疱疹病毒感染中的可能作用。
