阴道髓样树突状细胞传播初始HIV-1。
Vaginal myeloid dendritic cells transmit founder HIV-1.
作者信息
Shen Ruizhong, Kappes John C, Smythies Lesley E, Richter Holly E, Novak Lea, Smith Phillip D
机构信息
Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, USA
Department of Medicine (Hematology/Oncology), University of Alabama at Birmingham, Birmingham, Alabama, USA VA Medical Center Research Service, Birmingham, Alabama, USA.
出版信息
J Virol. 2014 Jul;88(13):7683-8. doi: 10.1128/JVI.00766-14. Epub 2014 Apr 16.
Abstract
We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13(+) CD11c(+) DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.
摘要
我们报告称，原代人阴道树突状细胞（DCs）呈现髓样表型，并表达CD4、CCR5和CXCR4。阴道CD13(+) CD11c(+) DCs能快速有效地结合传播/奠基（T/F）CCR5嗜性（R5）病毒，通过移植的阴道黏膜转运这些病毒，并将它们传递给阴道和血液中的淋巴细胞。阴道髓样DCs可能在体内捕获和传播T/F R5 HIV-1中起关键作用，并且是HIV-1传播中的候选“守门”细胞。
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