Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, AL, USA.
Am J Reprod Immunol. 2014 Jun;71(6):608-17. doi: 10.1111/aji.12244. Epub 2014 Apr 1.
Worldwide, the heterosexual route is the prevalent mode of HIV-1 transmission, and the female reproductive tract accounts for approximately 40% of all HIV-1 transmissions. HIV-1 infection in the female reproductive tract involves three major events: entry through the mucosal epithelium, productive infection in subepithelial mononuclear cells, and delivery to lymph nodes to initiate systemic infection. Here, we provide a focused review of the interaction between HIV-1 and mucosal epithelial cells, lymphocytes, macrophages, and dendritic cells in female genital mucosa. Increased understanding of these interactions could illuminate new approaches for interdicting HIV-1 heterosexual transmission.
在全球范围内，异性传播是 HIV-1 传播的主要途径，而女性生殖道约占所有 HIV-1 传播的 40%。HIV-1 在女性生殖道的感染涉及三个主要事件：通过黏膜上皮进入、在下皮单核细胞中进行有性感染、以及传播到淋巴结以启动全身感染。在这里，我们重点回顾了 HIV-1 与女性生殖道黏膜上皮细胞、淋巴细胞、巨噬细胞和树突状细胞之间的相互作用。对这些相互作用的深入了解可以为阻断 HIV-1 异性传播提供新的方法。
