胃癌细胞中 Bcl-2 和 BID 的表达。
The expression of Bcl-2 and BID in gastric cancer cells.
机构信息
Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
Department of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, Poland.
出版信息
J Immunol Res. 2014;2014:953203. doi: 10.1155/2014/953203. Epub 2014 Feb 19.
BACKGROUND
Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients' survival.
MATERIALS AND METHODS
The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically.
RESULTS
Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer (P < 0.05), with the intestinal type according to Lauren (P < 0.001), ulcerated type according to Bormann's classification (P < 0.01), and with local lymph node metastases (P < 0.05).
CONCLUSION
The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.
背景
Bcl-2 和 BID 在细胞凋亡过程中起主要作用，其功能障碍是致癌作用的基础。本研究的目的是评估胃癌细胞中 Bcl-2 和 BID 的表达与选择的临床病理参数、幽门螺杆菌感染和患者生存的相关性。
材料与方法
本研究共纳入 88 例行胃癌手术的患者。采用免疫组织化学法检测 Bcl-2 和 BID 的表达。
结果
阳性 Bcl-2 表达见于 55.7%的患者，BID 见于 53.6%的患者。Bcl-2 的表达与胃癌 pT3 和 T4 期（P < 0.05）、Lauren 分类的肠型（P < 0.001）、Bormann 分类的溃疡型（P < 0.01）和局部淋巴结转移（P < 0.05）相关。
结论
Bcl-2 蛋白在胃癌形成过程中起关键作用，并与特定类型的胃癌生长相关。
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