高级听觉皮层中与任务相关的刺激的紧急选择性。
Emergent selectivity for task-relevant stimuli in higher-order auditory cortex.
机构信息
Institute for Systems Research, Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA; BRAMS, Montreal Neurological Institute, McGill University, Montreal, QE H3A 2B4, Canada.
Institute for Systems Research, Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA; Oregon Hearing Research Center, Oregon Health and Science University, Portland, OR 97239, USA.
出版信息
Neuron. 2014 Apr 16;82(2):486-99. doi: 10.1016/j.neuron.2014.02.029.
A variety of attention-related effects have been demonstrated in primary auditory cortex (A1). However, an understanding of the functional role of higher auditory cortical areas in guiding attention to acoustic stimuli has been elusive. We recorded from neurons in two tonotopic cortical belt areas in the dorsal posterior ectosylvian gyrus (dPEG) of ferrets trained on a simple auditory discrimination task. Neurons in dPEG showed similar basic auditory tuning properties to A1, but during behavior we observed marked differences between these areas. In the belt areas, changes in neuronal firing rate and response dynamics greatly enhanced responses to target stimuli relative to distractors, allowing for greater attentional selection during active listening. Consistent with existing anatomical evidence, the pattern of sensory tuning and behavioral modulation in auditory belt cortex links the spectrotemporal representation of the whole acoustic scene in A1 to a more abstracted representation of task-relevant stimuli observed in frontal cortex.
已在初级听觉皮层（A1）中证明了多种与注意力相关的效应。然而，对于高听觉皮质区域在引导对声刺激的注意力方面的功能作用，我们仍知之甚少。我们在接受简单听觉辨别任务训练的雪貂背侧后外侧圆叶（dPEG）的两个音调皮质带区域中记录神经元。dPEG 中的神经元表现出与 A1 相似的基本听觉调谐特性，但在行为过程中，我们观察到这些区域之间存在明显差异。在带区中，神经元放电率和反应动力学的变化极大地增强了对目标刺激的反应，相对于干扰刺激，从而在主动聆听期间实现了更大的注意力选择。与现有的解剖学证据一致，听觉带皮质的感觉调谐和行为调节模式将 A1 中整个声场景的频谱时间表示与在额叶皮质中观察到的与任务相关刺激的更抽象表示联系起来。
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