Varela A, Felip M N, Montesi A, Savino E A
Orientación Fisiología Humana, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina.
Arch Int Physiol Biochim. 1988 Dec;96(5):165-70. doi: 10.3109/13813458809075940.
The peak developed tension and the pacemaker frequency of the isolated atria from fed and fasted rats, declined progressively during the incubation in a glucose-free medium containing 2-deoxyglucose. The atria from fed rats exhibited a faster decline than those from fasted rats, which was associated to a slower triacylglycerol lipolysis. 4-Pentenoic acid inhibited the lipolysis of both groups of atria but did not alter the atrial contractile performance. However, it enhanced the decline of the pacemaker frequency in the atria from fasted rats whereas, in contrast, it alleviated the decline in the fed atria. n-Pentanoic acid ameliorated the impairment of the contractile and pacemaker activities in both groups of atria, without affecting the lipolysis. It was concluded that, since the inhibition of the intramyocardial lipolysis did not correlate with changes of the atrial functions, 4-pentenoic acid was not appropriate to assess about the contribution of endogenous triacylglycerol to the maintenance of the atrial contractile and pacemaker activities.
在含有2-脱氧葡萄糖的无葡萄糖培养基中孵育期间，喂食和禁食大鼠分离心房的最大舒张张力和起搏频率逐渐下降。喂食大鼠的心房比禁食大鼠的心房下降得更快，这与三酰甘油脂解较慢有关。4-戊烯酸抑制两组心房的脂解，但不改变心房收缩性能。然而，它增强了禁食大鼠心房起搏频率的下降，而相反，它减轻了喂食大鼠心房的下降。正戊酸改善了两组心房收缩和起搏活动的损伤，而不影响脂解。得出的结论是，由于心肌内脂解的抑制与心房功能的变化不相关，4-戊烯酸不适用于评估内源性三酰甘油对维持心房收缩和起搏活动的贡献。
