2-脱氧-D-葡萄糖对喂食及禁食大鼠离体心房收缩频率的影响。

Effects of 2-deoxy-D-glucose on the contraction frequency of the isolated atria from fed and fasted rats.

作者信息

Oliva E A, Savino E A

出版信息

Arch Int Physiol Biochim. 1979 Feb;87(1):59-63. doi: 10.3109/13813457909070485.

Abstract

The mere exogenous substrate removal did not change the contraction frequency of the isolated rat atria. However, addition of 2-deoxy-D-glucose together with the glucose removal, elicited a decrease in the atrial frequency. This decrease was significantly greater in the atria from fed rats with respect to those from fasted rats. Near the end of the experiments, only in the atria from fed rats, transient irregular beating appeared. The results suggest that triglycerides constitute the major endogenous substrate of the sinus node pacemaker cells when rats have been previously fasted and that these cells have metabolic features similar to those of contractile fibres.

摘要

单纯的外源性底物去除并未改变离体大鼠心房的收缩频率。然而，在去除葡萄糖的同时添加2-脱氧-D-葡萄糖，会引起心房频率降低。与禁食大鼠的心房相比，喂食大鼠的心房频率降低幅度显著更大。在实验接近尾声时，仅喂食大鼠的心房出现了短暂的不规则搏动。结果表明，在大鼠预先禁食的情况下，甘油三酯构成窦房结起搏细胞的主要内源性底物，且这些细胞具有与收缩性纤维相似的代谢特征。