Tizaoui Kalthoum, Kaabachi Wajih, Hamzaoui Agnès, Hamzaoui Kamel
Tunis El Manar University, Faculty of Medicine Tunis, Division of Histology and Immunology Department of Basic Sciences, 15 Rue Djebel Lakdar, 1007 Tunis, Tunisia.
Tunis El Manar University, Faculty of Medicine Tunis, Division of Histology and Immunology Department of Basic Sciences, 15 Rue Djebel Lakdar, 1007 Tunis, Tunisia.
J Steroid Biochem Mol Biol. 2014 Sep;143:240-9. doi: 10.1016/j.jsbmb.2014.03.011. Epub 2014 Apr 15.
Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in type 1 diabetes (T1D). However, the results are inconsistent and inconclusive. The current study aimed to investigate the role of TaqI, BsmI, ApaI and FokI VDR polymorphisms in T1D disease. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, a systematic search and meta-analysis of the literature, since 1998 until december 2013, was conducted. Subgroup analyses were performed to detect potential sources of heterogeneity from selected study characteristics. Meta-analyses yielded a non-significant association of TaqI polymorphism with T1D [OR=1.014 (0.783-1.312); P=0.918] in the recessive model. The BsmI polymorphism was not associated with T1D [OR=1.44 (0.944-1.386); P=0.171] in the dominant model. Also, ApaI polymorphism was not associated with T1D risk [OR=0.996 (0.859-1.155); P=0.960] in the homozygous model. The FokI polymorphism was not associated with T1D risk [OR=0.968 (0.743-1.263); P=0.813] in dominant model. Stratification according to study characteristics showed that publication year, age, gender, estimated vitamin D levels and latitude moderated significantly association between VDR polymorphisms and T1D disease. Meta-analysis on haplotypes revealed that BAT might be a significant risk factor for T1D [OR=1.331 (0.957-1.850; P=0.089]. However, the bAT was found to be a significant protective factor [OR=0.639 (0.460-0.887); P=0.007]. As conclusion, individual VDR polymorphisms seemed not to be associated with T1D risk. However, haplotypes contributed significantly to disease susceptibility. Study characteristics moderated the association between VDR polymorphisms and T1D. These results suggested that, in T1D pathogenesis, VDR polymorphisms interact with each other and with environmental factors.
维生素D受体（VDR）基因多态性在1型糖尿病（T1D）中的研究结果并不一致。然而，这些结果并不一致且尚无定论。本研究旨在探讨TaqI、BsmI、ApaI和FokI VDR基因多态性在T1D疾病中的作用。按照系统评价和Meta分析的首选报告项目（PRISMA）指南，对1998年至2013年12月的文献进行了系统检索和Meta分析。进行亚组分析以检测选定研究特征中潜在的异质性来源。Meta分析结果显示，在隐性模型中，TaqI基因多态性与T1D无显著关联[比值比（OR）=1.014（0.783 - 1.312）；P = 0.918]。在显性模型中，BsmI基因多态性与T1D无关联[OR = 1.44（0.944 - 1.386）；P = 0.171]。同样，在纯合子模型中，ApaI基因多态性与T1D风险无关联[OR = 0.996（0.859 - 1.155）；P = 0.960]。在显性模型中，FokI基因多态性与T1D风险无关联[OR = 0.968（0.743 - 1.263）；P = 0.813]。根据研究特征进行分层分析表明，发表年份、年龄、性别、估计维生素D水平和纬度显著影响VDR基因多态性与T1D疾病之间的关联。单倍型Meta分析显示，BAT可能是T1D的一个显著风险因素[OR = 1.331（0.957 - 1.850；P = 0.089]。然而，发现bAT是一个显著的保护因素[OR = 0.639（0.460 - 0.887）；P = 0.007]。综上所述，个体VDR基因多态性似乎与T1D风险无关。然而，单倍型对疾病易感性有显著影响。研究特征影响VDR基因多态性与T1D之间的关联。这些结果表明，在T1D发病机制中，VDR基因多态性相互作用并与环境因素相互作用。
