Tizaoui Kalthoum, Hamzaoui Kamel
Tunis El Manar University, Faculty of Medicine Tunis, Division of Histology and Immunology, Department of Basic Sciences, 15 Rue Djebel Lakdar, 1007 Tunis, Tunisia.
Tunis El Manar University, Faculty of Medicine Tunis, Division of Histology and Immunology, Department of Basic Sciences, 15 Rue Djebel Lakdar, 1007 Tunis, Tunisia.
Immunobiology. 2015 Jun;220(6):807-16. doi: 10.1016/j.imbio.2014.12.013. Epub 2014 Dec 30.
Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in rheumatoid arthritis (RA). However, published studies demonstrated differences concerning design and effect size. A meta-analysis is necessary to determine the magnitude of the association between VDR polymorphisms and RA risk.
The aim of the current study was to quantify the magnitude of the association between TaqI, BsmI, and FokI VDR polymorphisms with RA risk.
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search and meta-analysis of the literature were conducted. Analyses were performed in the random effects model by using recessive, dominant, codominant, homozygous, and allele contrast models.
A total of 1703 cases and 2635 controls in 12 case-control studies were included in the meta-analyses. Results indicated a significant association between TaqI polymorphism and RA disease in homozygous, codominant and allele contrast models (P=0.008, P=0.015, P=0.006 and P=0.002, respectively). Association between BsmI polymorphism and RA risk was marginal in the dominant, codominant and allele contrast models (P=0.057, P=0.071, and P=0.069, respectively). Te association between FokI polymorphism and RA risk was significant in the recessive, dominant and allele contrast models (P=0.045, P=0.027, and P=0.013, respectively). Subgroup analysis showed that publication year, ethnicity, age, latitude, and estimated 25(OH)D levels influenced significantly the association between VDR polymorphisms and RA risk.
TaqI and FokI VDR polymorphisms contributed significantly to RA risk. Study characteristics influenced the association between VDR polymorphisms and RA disease.
维生素D受体（VDR）基因多态性在类风湿关节炎（RA）中的研究结果并不一致。然而，已发表的研究在设计和效应大小方面存在差异。有必要进行一项荟萃分析来确定VDR基因多态性与RA风险之间关联的程度。
本研究的目的是量化TaqI、BsmI和FokI VDR基因多态性与RA风险之间关联的程度。
按照系统评价和荟萃分析的首选报告项目（PRISMA）指南，对文献进行了系统检索和荟萃分析。采用随机效应模型，通过隐性、显性、共显性、纯合子和等位基因对比模型进行分析。
荟萃分析纳入了12项病例对照研究中的1703例病例和2635例对照。结果表明，在纯合子、共显性和等位基因对比模型中，TaqI基因多态性与RA疾病之间存在显著关联（分别为P=0.008、P=0.015、P=0.006和P=0.002）。在显性、共显性和等位基因对比模型中，BsmI基因多态性与RA风险之间的关联微弱（分别为P=0.057、P=0.071和P=0.069）。在隐性、显性和等位基因对比模型中，FokI基因多态性与RA风险之间的关联显著（分别为P=0.045、P=0.027和P=0.013）。亚组分析表明，发表年份、种族、年龄、纬度和估计的25（OH）D水平显著影响VDR基因多态性与RA风险之间的关联。
TaqI和FokI VDR基因多态性对RA风险有显著影响。研究特征影响VDR基因多态性与RA疾病之间的关联。
