Scripps Research Institute, Department of Chemistry, Jupiter, Florida, USA.
Nat Chem Biol. 2014 May;10(5):327-8. doi: 10.1038/nchembio.1504.
Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this process represents a new role for the protein arginine deiminases (PADs) in development.
多能干细胞状态的维持受组蛋白翻译后修饰的调控。组蛋白连接子 H1 的瓜氨酸化对这一过程至关重要，这一发现代表了蛋白精氨酸脱亚氨酶（PADs）在发育过程中的新作用。
