National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, United Kingdom.
National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, United Kingdom Department of Epidemiology and Genetics, Institute of Ophthalmology, London, United Kingdom.
Invest Ophthalmol Vis Sci. 2014 Apr 17;55(5):3303-10. doi: 10.1167/iovs.13-13756.
Pigment dispersion syndrome is associated with iris concavity. This study investigated the prevalence of iris concavity, defined as a measurement of ≤-0.1 mm, in a cohort of 10- to 12-year-old boys, and explored the relationship between iris curvature and anterior segment biometry. Associations with corneal biomechanical parameters also were explored.
A cohort of school boys (n = 96) was recruited from a local school. Anterior segment optical coherence tomography (AS-OCT) was performed under accommodative and nonaccommodative conditions, and iris curvature quantified. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with the ocular response analyzer (ORA). Noncontact axial biometry was performed using laser interferometry.
The prevalence of iris concavity was 24% on distance fixation, increasing to 65% on accommodation. Variables significantly associated with nonaccommodating iris curvature were lens vault (P = 0.02) and mean keratometry (P = 0.02). For both variables acting jointly, R(2) = 0.30. Variables associated significantly with accommodating iris curvature were anterior chamber depth (P = 0.009), lens vault (P = 0.049), and mean scleral spur angle (P < 0.0001). For these three variables acting jointly, R(2) = 0.33. Significant association was found between CH and spur-to-spur distance (R(2) = 0.07, P = 0.025).
Iris concavity was a common finding in this cohort and related to anterior segment biometric parameters. Further work is required to clarify whether anatomical differences exist between iris concavity seen in the adolescent eye and that found in adults with pigment dispersion syndrome.
色素播散综合征与虹膜凹陷有关。本研究调查了 10 至 12 岁男孩队列中虹膜凹陷（定义为测量值≤-0.1mm）的患病率，并探讨了虹膜曲率与眼前节生物测量学之间的关系。还探讨了与角膜生物力学参数的相关性。
从当地一所学校招募了一组男校学生（n=96）。在调节和非调节条件下进行眼前节光学相干断层扫描（AS-OCT），并定量测量虹膜曲率。使用眼反应分析仪（ORA）测量角膜滞后（CH）和角膜阻力因子（CRF）。使用激光干涉仪进行非接触轴向生物测量。
在远距离固定时，虹膜凹陷的患病率为 24%，在调节时增加到 65%。与非调节性虹膜曲率显著相关的变量是晶状体拱顶（P=0.02）和平均角膜曲率（P=0.02）。对于这两个变量共同作用，R²=0.30。与调节性虹膜曲率显著相关的变量是前房深度（P=0.009）、晶状体拱顶（P=0.049）和平均巩膜突角（P<0.0001）。对于这三个变量共同作用，R²=0.33。在 CH 和突距之间发现了显著的相关性（R²=0.07，P=0.025）。
在本队列中，虹膜凹陷是一种常见发现，与眼前节生物测量参数有关。需要进一步的工作来阐明在青少年眼中看到的虹膜凹陷与色素播散综合征中发现的成年人的虹膜凹陷之间是否存在解剖差异。
