National Institute of Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, United Kingdom.
National Institute of Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, United Kingdom Department of Epidemiology and Genetics, Institute of Ophthalmology, London, United Kingdom.
Invest Ophthalmol Vis Sci. 2014 Jun 10;55(7):4645-50. doi: 10.1167/iovs.13-13757.
To explore changes in iris curvature over a 2-year period. To investigate associations between iris curvature and ocular biometric parameters. To explore relationships between a number of nonocular measurements and ocular biometric parameters.
Schoolboys enrolled 2 years previously were invited to return for anterior segment optical coherence tomography, corneal hysteresis (CH), corneal resistance factor (CRF), and axial biometric measurements. Refractive error was assessed and measures of height, weight, waist circumference, digit ratio, and percentage body fat taken.
Mean spherical equivalent refraction reduced by 0.76 diopters and mean iris concavity, defined as a measurement of less than or equal to -0.1 mm, increased by 0.018 mm at distance fixation and 0.04 mm on accommodation. Compared with 2 years previously, the prevalence of iris concavity increased from 24% to 32% on distance fixation and from 65% to 84% on accommodation. Variables significantly associated with nonaccommodating iris curvature were anterior chamber depth (ACD, P = 0.029) and mean scleral spur angle (P = 0.0001). Variables significantly associated with accommodating iris curvature were ACD (P = 0.02), lens vault (P = 0.047), and scleral spur angle (P < 0.0001). Significant association was again found between CH and accommodating spur-to-spur distance (R(2) = 0.13, P = 0.007).
Iris concavity was more prevalent in this cohort of schoolboys than 2 years earlier. The degree of concavity remains related to ACD and lens vault. The association between spur-to-spur distance and CH was similar at baseline and after 2 years.
探索 2 年内虹膜曲率的变化。研究虹膜曲率与眼部生物测量参数之间的关系。探讨许多非眼部测量值与眼部生物测量参数之间的关系。
邀请 2 年前入组的男校生返回进行眼前节光学相干断层扫描、角膜滞后（CH）、角膜阻力因子（CRF）和轴向生物测量测量。评估屈光不正，并测量身高、体重、腰围、指比和体脂百分比。
平均球镜屈光度降低了 0.76 屈光度，平均虹膜凹陷度（定义为等于或小于-0.1mm 的测量值）在远距固定时增加了 0.018mm，在调节时增加了 0.04mm。与 2 年前相比，远距固定时虹膜凹陷的患病率从 24%增加到 32%，从 65%增加到 84%。与非调节性虹膜曲率显著相关的变量是前房深度（ACD，P=0.029）和平均巩膜突角（P=0.0001）。与调节性虹膜曲率显著相关的变量是 ACD（P=0.02）、晶状体 vault（P=0.047）和巩膜突角（P<0.0001）。再次发现 CH 与调节性 spur-to-spur 距离之间存在显著相关性（R²=0.13，P=0.007）。
与 2 年前相比，该男校生队列中虹膜凹陷更为普遍。凹陷程度仍与 ACD 和晶状体 vault 有关。基线时和 2 年后 spur-to-spur 距离与 CH 之间的相关性相似。
