难以分类的震颤患者和 DaT-SPECT 正常患者的诊断背后：一项临床随访研究。
Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study.
机构信息
Neurology Unit, Hospital Álvarez-Buylla Mieres, Spain ; Morphology and Cellular Biology Department, Universidad de Oviedo Oviedo, Spain ; Instituto de Neurociencias, Universidad de Oviedo Oviedo, Spain.
Family Medicine, Hospital Álvarez-Buylla Mieres, Spain.
出版信息
Front Aging Neurosci. 2014 Apr 1;6:56. doi: 10.3389/fnagi.2014.00056. eCollection 2014.
The [(123)I]ioflupane-a dopamine transporter radioligand-SPECT (DaT-SPECT) has proven to be useful in the differential diagnosis of tremor. Here, we investigate the diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT. Therefore, 30 patients with tremor and normal DaT-SPECT were followed up for 2 years. In 18 cases we were able to make a diagnosis. The residual 12 patients underwent a second DaT-SPECT, were then followed for additional 12 months and thereafter the diagnosis was reconsidered again. The final diagnoses included cases of essential tremor, dystonic tremor, multisystem atrophy, vascular parkinsonism, progressive supranuclear palsy, corticobasal degeneration, fragile X-associated tremor ataxia syndrome, psychogenic parkinsonism, iatrogenic parkinsonism and Parkinson's disease. However, for 6 patients the diagnosis remained uncertain. Larger series are needed to better establish the relative frequency of the different conditions behind these cases.
[(123)I]碘[^123^]比曲班[^123^]-多巴胺转运体 SPECT（DaT-SPECT）已被证明在震颤的鉴别诊断中有用。在这里，我们研究了难以分类的震颤和正常 DaT-SPECT 背后的诊断。因此，对 30 名震颤和正常 DaT-SPECT 的患者进行了 2 年的随访。在 18 例中，我们能够做出诊断。其余 12 名患者接受了第二次 DaT-SPECT 检查，然后再随访 12 个月，然后再次重新考虑诊断。最终诊断包括特发性震颤、肌张力障碍性震颤、多系统萎缩、血管性帕金森病、进行性核上性麻痹、皮质基底节变性、脆性 X 相关震颤共济失调综合征、精神性帕金森病、医源性帕金森病和帕金森病。然而，对于 6 名患者，诊断仍不确定。需要更大的系列来更好地确定这些病例背后不同情况的相对频率。
[^123^]碘[^123^]比曲班[^123^]：碘[^123^]比曲班[^123^]（Iodine[^123^]Ioflupane）是一种正电子发射断层扫描（PET）示踪剂，常用于诊断帕金森病和其他与多巴胺能神经元功能障碍相关的疾病。它与多巴胺转运体（DAT）结合，通过 PET 扫描可以观察到其在脑内的分布情况，从而评估多巴胺能神经元的数量和功能。
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