Labiano-Fontcuberta Andrés, Benito-León Julián
Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.
Rev Neurol. 2012 Oct 16;55(8):479-89.
There is now growing evidence that essential tremor and Parkinson's disease are related.
To present the main findings from epidemiologic, genetic, clinical, imaging and pathologic studies, contrasting evidences for and against an association between essential tremor and Parkinson's disease.
We include a complete update of the latest findings regarding the overlap between these two disorders. There is current evidence that a history of essential tremor may herald the onset of Parkinson's disease in a subset of patients. Furthermore, the fact that the risk of essential tremor is significantly increased in relatives of patients with Parkinson's disease suggests the possibility that both conditions are genetically related, probably sharing common hereditary predisposition. Dopaminergic deficit among essential tremor patients in functional imaging studies and recent pathological studies describing Lewy bodies in some essential tremor patients, support further evidence for an overlap between both conditions, at least in a subset of patients.
The convergence of all the reviewed data suggests the possible existence of a mixed essential tremor-Parkinson's disease phenotype in some patients. However, further studies are needed to better understand this phenotype.
目前越来越多的证据表明特发性震颤与帕金森病有关。
介绍流行病学、遗传学、临床、影像学和病理学研究的主要发现，对比支持和反对特发性震颤与帕金森病之间存在关联的证据。
我们全面更新了关于这两种疾病重叠的最新研究结果。目前有证据表明，在一部分患者中，特发性震颤病史可能预示着帕金森病的发病。此外，帕金森病患者亲属患特发性震颤的风险显著增加，这表明这两种疾病可能在遗传上相关，可能具有共同的遗传易感性。功能影像学研究中特发性震颤患者存在多巴胺能缺陷，以及近期病理学研究描述了一些特发性震颤患者存在路易小体，这些都进一步支持了至少在一部分患者中这两种疾病存在重叠的证据。
所有综述数据的趋同表明，在一些患者中可能存在特发性震颤 - 帕金森病混合表型。然而，需要进一步研究以更好地理解这种表型。
